LINC00680

Summary

LINC00680 (long intergenic non-protein coding RNA 680, HGNC:44417) is a unprocessed pseudogene on chromosome 6p11.2.

At a glance

• Gene type: non-coding (transcribed_unprocessed_pseudogene) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44417
Approved symbol	LINC00680
Name	long intergenic non-protein coding RNA 680
Location	6p11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000215190
Ensembl biotype	transcribed_unprocessed_pseudogene
Entrez	106660612
RNAcentral	URS00008E3957 — lncRNA, 1989 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 transcribed_unprocessed_pseudogene

ENST00000635948

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635948 — 3 exons

Exon	Start	End
ENSE00001561759	57961152	57961224
ENSE00003794080	57961321	57961345
ENSE00003797938	57959029	57959111

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 83.37.

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	83.37	silver quality
apex of heart	UBERON:0002098	82.56	gold quality
corpus callosum	UBERON:0002336	80.49	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.37	gold quality
granulocyte	CL:0000094	78.26	gold quality
stromal cell of endometrium	CL:0002255	77.08	gold quality
cortical plate	UBERON:0005343	77.00	gold quality
prefrontal cortex	UBERON:0000451	76.90	gold quality
heart left ventricle	UBERON:0002084	76.74	gold quality
frontal cortex	UBERON:0001870	76.72	gold quality
hypothalamus	UBERON:0001898	76.72	gold quality
superior frontal gyrus	UBERON:0002661	76.72	gold quality
ganglionic eminence	UBERON:0004023	76.71	gold quality
primary visual cortex	UBERON:0002436	76.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	76.60	gold quality
lower esophagus mucosa	UBERON:0035834	76.36	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.35	gold quality
right frontal lobe	UBERON:0002810	76.30	gold quality
anterior cingulate cortex	UBERON:0009835	76.26	gold quality
cerebral cortex	UBERON:0000956	76.24	gold quality
quadriceps femoris	UBERON:0001377	76.07	gold quality
adenohypophysis	UBERON:0002196	75.96	gold quality
heart	UBERON:0000948	75.64	gold quality
pituitary gland	UBERON:0000007	75.31	gold quality
leukocyte	CL:0000738	75.30	gold quality
mucosa of stomach	UBERON:0001199	75.26	gold quality
calcaneal tendon	UBERON:0003701	75.26	gold quality
monocyte	CL:0000576	75.17	gold quality
metanephros cortex	UBERON:0010533	75.03	gold quality
thoracic aorta	UBERON:0001515	74.96	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-36552	yes	141.68
E-MTAB-7008	yes	9.95
E-ANND-3	no	2.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LINC00680 enhances hepatocellular carcinoma stemness behavior and chemoresistance by sponging miR-568 to upregulate AKT3. (PMID:33499874)
• LncRNA LINC00680 promotes lung adenocarcinoma growth via binding to GATA6 and canceling GATA6-mediated suppression of SOX12 expression. (PMID:34029572)
• Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis. (PMID:35255921)
• LINC00680 modulates docetaxel resistance in breast cancer via the miR-320b/CDKL5 axis. (PMID:35667653)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.