LINC00681

Summary

LINC00681 (long intergenic non-protein coding RNA 681, HGNC:44423) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44423
Approved symbol	LINC00681
Name	long intergenic non-protein coding RNA 681
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000255494
Ensembl biotype	lncRNA
Entrez	101409254
RNAcentral	URS0000ABD8C2 — lncRNA, 525 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000530150, ENST00000795276, ENST00000795277, ENST00000795278

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000530150 — 2 exons

Exon	Start	End
ENSE00002183537	12817963	12818292
ENSE00004179807	12794231	12794417

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 95.74.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0151 / max 7.2321, expressed in 6 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
87456	0.0093	6
87455	0.0058	3

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	95.74	gold quality
skin of leg	UBERON:0001511	70.91	gold quality
zone of skin	UBERON:0000014	69.11	gold quality
ganglionic eminence	UBERON:0004023	67.40	gold quality
ventricular zone	UBERON:0003053	67.20	gold quality
skin of abdomen	UBERON:0001416	66.24	gold quality
left uterine tube	UBERON:0001303	62.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.61	gold quality
endocervix	UBERON:0000458	58.61	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.30	gold quality
placenta	UBERON:0001987	57.94	gold quality
calcaneal tendon	UBERON:0003701	55.70	gold quality
multicellular organism	UBERON:0000468	55.64	gold quality
prefrontal cortex	UBERON:0000451	55.26	gold quality
superior frontal gyrus	UBERON:0002661	53.62	gold quality
liver	UBERON:0002107	53.60	gold quality
gastrocnemius	UBERON:0001388	51.20	gold quality
monocyte	CL:0000576	51.08	silver quality
ectocervix	UBERON:0012249	51.00	gold quality
primary visual cortex	UBERON:0002436	50.54	gold quality
blood	UBERON:0000178	50.43	gold quality
tibial artery	UBERON:0007610	48.45	gold quality
heart left ventricle	UBERON:0002084	47.89	gold quality
endometrium	UBERON:0001295	47.73	gold quality
right lobe of liver	UBERON:0001114	47.57	silver quality
cortex of kidney	UBERON:0001225	47.50	gold quality
kidney	UBERON:0002113	47.28	gold quality
body of uterus	UBERON:0009853	46.20	gold quality
myometrium	UBERON:0001296	45.85	gold quality
putamen	UBERON:0001874	45.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.40

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.