LINC00689

Summary

LINC00689 (long intergenic non-protein coding RNA 689, HGNC:27217) is a long non-coding RNA gene on chromosome 7q36.3.

Implicated in colorectal cancer.

Source: NCBI Gene 154822 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27217
Approved symbol	LINC00689
Name	long intergenic non-protein coding RNA 689
Location	7q36.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	STORM
Ensembl gene	ENSG00000231419
Ensembl biotype	lncRNA
Entrez	154822
RNAcentral	URS000075E164 — lncRNA, 4082 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000413238, ENST00000417032, ENST00000438049, ENST00000447563, ENST00000737528, ENST00000737529, ENST00000737530, ENST00000737531, ENST00000737532, ENST00000737533, ENST00000737534

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000413238 — 6 exons

Exon	Start	End
ENSE00001620069	159021673	159021797
ENSE00001711037	159026240	159030195
ENSE00001744545	159016458	159017646
ENSE00004071907	159012996	159013213
ENSE00004071909	159020485	159020848
ENSE00004071921	159013955	159014084

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 87.87.

Top tissues by expression

227 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	87.87	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.33	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.14	gold quality
apex of heart	UBERON:0002098	67.98	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.85	gold quality
ventricular zone	UBERON:0003053	65.40	gold quality
granulocyte	CL:0000094	63.19	gold quality
heart left ventricle	UBERON:0002084	62.21	gold quality
thoracic aorta	UBERON:0001515	62.13	gold quality
ascending aorta	UBERON:0001496	62.03	gold quality
aorta	UBERON:0000947	61.52	gold quality
cardiac ventricle	UBERON:0002082	61.51	gold quality
popliteal artery	UBERON:0002250	61.28	gold quality
tibial artery	UBERON:0007610	61.25	gold quality
descending thoracic aorta	UBERON:0002345	60.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.87	gold quality
muscle of leg	UBERON:0001383	60.67	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	60.48	gold quality
mucosa of stomach	UBERON:0001199	60.05	gold quality
gastrocnemius	UBERON:0001388	59.37	gold quality
heart	UBERON:0000948	58.35	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.54	gold quality
oviduct epithelium	UBERON:0004804	57.00	gold quality
right atrium auricular region	UBERON:0006631	56.65	gold quality
cardiac atrium	UBERON:0002081	56.23	gold quality
omental fat pad	UBERON:0010414	55.89	gold quality
peritoneum	UBERON:0002358	55.84	gold quality
vena cava	UBERON:0004087	55.09	gold quality
adipose tissue of abdominal region	UBERON:0007808	54.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	54.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Study reports for a first time an association of a (3’ UTR) variant rs885863 in VIPR2 gene and opioid addiction. This single nucleotide polymorphism is an expression quantitative trait locus for VIPR2 and a long intergenic non-coding RNA, lincRNA 689. The study provides preliminary insight into the relationship between genetic variants in circadian rhythm genes and lincRNA in their vicinity, and opioid addiction. (PMID:31689297)
• SP1-induced lncRNA LINC00689 overexpression contributes to osteosarcoma progression via the miR-655/SOX18 axis. (PMID:32196572)
• LINC00689 induces gastric cancer progression via modulating the miR-338-3p/HOXA3 axis. (PMID:32926751)
• LncRNA LINC00689 Promotes the Tumorigenesis of Glioma via Mediation of miR-526b-3p/IGF2BP1 Axis. (PMID:33389570)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.