LINC00691

Summary

LINC00691 (long intergenic non-protein coding RNA 691, HGNC:44514) is a long non-coding RNA gene on chromosome 3p24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44514
Approved symbol	LINC00691
Name	long intergenic non-protein coding RNA 691
Location	3p24.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224074
Ensembl biotype	lncRNA
Entrez	152024
RNAcentral	URS000075AF7B — lncRNA, 2241 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000432505, ENST00000436123

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432505 — 2 exons

Exon	Start	End
ENSE00001711168	24102580	24103238
ENSE00001730090	24099974	24101546

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 77.51.

Top tissues by expression

167 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	77.51	silver quality
buccal mucosa cell	CL:0002336	68.94	silver quality
bone marrow cell	CL:0002092	64.32	silver quality
hindlimb stylopod muscle	UBERON:0004252	59.80	gold quality
cortical plate	UBERON:0005343	59.54	silver quality
upper lobe of lung	UBERON:0008948	58.93	silver quality
superficial temporal artery	UBERON:0001614	58.87	gold quality
lower lobe of lung	UBERON:0008949	58.77	silver quality
epithelium of nasopharynx	UBERON:0001951	58.17	gold quality
amniotic fluid	UBERON:0000173	57.67	gold quality
gingival epithelium	UBERON:0001949	56.96	gold quality
endothelial cell	CL:0000115	56.24	gold quality
mucosa of paranasal sinus	UBERON:0005030	56.18	gold quality
left testis	UBERON:0004533	55.28	gold quality
myocardium	UBERON:0002349	54.73	gold quality
testis	UBERON:0000473	54.66	gold quality
mammary duct	UBERON:0001765	54.31	gold quality
right lobe of liver	UBERON:0001114	54.24	gold quality
right testis	UBERON:0004534	53.88	gold quality
tendon of biceps brachii	UBERON:0008188	53.73	gold quality
tibia	UBERON:0000979	53.61	gold quality
gingiva	UBERON:0001828	52.15	gold quality
skin of hip	UBERON:0001554	51.39	silver quality
seminal vesicle	UBERON:0000998	51.34	gold quality
pigmented layer of retina	UBERON:0001782	51.14	gold quality
nasal cavity epithelium	UBERON:0005384	50.99	gold quality
oral cavity	UBERON:0000167	50.65	gold quality
caput epididymis	UBERON:0004358	50.61	gold quality
corpus epididymis	UBERON:0004359	50.59	gold quality
anterior cingulate cortex	UBERON:0009835	50.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Overexpression of LINC00691 promotes the proliferation and invasion of gastric cancer cells via the Janus kinase/signal transducer and activator of transcription signalling pathway. (PMID:32330554)
• Increased levels of long noncoding RNA LINC00691 correlate with poor prognosis in non-small-cell lung cancer patients. (PMID:32420681)
• Curcumin Inhibits Papillary Thyroid Cancer Cell Proliferation by Regulating lncRNA LINC00691. (PMID:35256924)
• Exosomes-mediated transfer of LINC00691 regulates the formation of CAFs and promotes the progression of gastric cancer. (PMID:37784036)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.