LINC00693

Summary

LINC00693 (long intergenic non-protein coding RNA 693, HGNC:44526) is a long non-coding RNA gene on chromosome 3p24.1.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 2 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44526
Approved symbol	LINC00693
Name	long intergenic non-protein coding RNA 693
Location	3p24.1
Locus type	RNA, long non-coding
Status	Approved
Entrez	645206
RNAcentral	URS000075E5E8 — lncRNA, 1666 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000013559 (3:28626809 A>G,T), RS1000034317 (3:28586070 A>G), RS1000063110 (3:28711437 G>A), RS1000066068 (3:28652884 G>A), RS1000077839 (3:28755939 A>T), RS1000078544 (3:28652482 T>C), RS1000099800 (3:28674960 G>T), RS1000118459 (3:28733644 C>G), RS1000130376 (3:28717612 A>G), RS1000131574 (3:28756222 A>G), RS1000133858 (3:28585869 T>G), RS1000157464 (3:28595715 G>T), RS1000188775 (3:28744758 G>A,T), RS1000229373 (3:28595447 C>T), RS1000239949 (3:28635361 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST002361_19	Smooth-surface caries	2.000000e-06
GCST004125_16	Type 2 diabetes (age of onset)	3.000000e-06
GCST004862_180	Itch intensity from mosquito bite adjusted by bite size	1.000000e-06
GCST004865_68	Itch intensity from mosquito bite adjusted by bite size	2.000000e-06
GCST009325_91	Parkinson’s disease or first degree relation to individual with Parkinson’s disease	8.000000e-12
GCST011741_26	LDL cholesterol levels in HIV infection	5.000000e-06

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008377	mosquito bite reaction itch intensity measurement
EFO:0008378	mosquito bite reaction size measurement
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	affects methylation	1
aflatoxin B2	decreases methylation	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	affects methylation	1
Methapyrilene	affects methylation	1
Propofol	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.