LINC00702

Summary

LINC00702 (long intergenic non-protein coding RNA 702, HGNC:44676) is a long non-coding RNA gene on chromosome 10p15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44676
Approved symbol	LINC00702
Name	long intergenic non-protein coding RNA 702
Location	10p15.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000233117
Ensembl biotype	lncRNA
Entrez	100652988
RNAcentral	URS000075E104 — lncRNA, 565 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 lncRNA

ENST00000418372, ENST00000454470, ENST00000608792, ENST00000654788, ENST00000655688, ENST00000658440, ENST00000658856, ENST00000659068, ENST00000659601, ENST00000661427, ENST00000662921, ENST00000663702, ENST00000665013, ENST00000666481, ENST00000668887, ENST00000668893, ENST00000841472, ENST00000841473, ENST00000841474, ENST00000841475, ENST00000841476, ENST00000841477, ENST00000841478, ENST00000841479, ENST00000841480

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418372 — 2 exons

Exon	Start	End
ENSE00001533958	4242950	4243109
ENSE00001727453	4243504	4243789

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 95.78.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7444 / max 88.6392, expressed in 611 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108030	1.2535	515
108029	0.4909	251

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
saphenous vein	UBERON:0007318	95.78	gold quality
right coronary artery	UBERON:0001625	94.70	gold quality
popliteal artery	UBERON:0002250	93.97	gold quality
tibial artery	UBERON:0007610	93.95	gold quality
aorta	UBERON:0000947	93.17	gold quality
calcaneal tendon	UBERON:0003701	92.91	gold quality
ascending aorta	UBERON:0001496	92.34	gold quality
thoracic aorta	UBERON:0001515	92.34	gold quality
left coronary artery	UBERON:0001626	90.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.57	gold quality
descending thoracic aorta	UBERON:0002345	90.41	gold quality
coronary artery	UBERON:0001621	90.39	gold quality
lower esophagus	UBERON:0013473	90.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	85.75	gold quality
tendon	UBERON:0000043	84.61	gold quality
smooth muscle tissue	UBERON:0001135	83.66	gold quality
right atrium auricular region	UBERON:0006631	83.36	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.89	gold quality
heart left ventricle	UBERON:0002084	82.81	gold quality
heart	UBERON:0000948	82.48	gold quality
cardiac ventricle	UBERON:0002082	82.38	gold quality
cardiac atrium	UBERON:0002081	82.01	gold quality
apex of heart	UBERON:0002098	80.73	gold quality
bone marrow cell	CL:0002092	79.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	79.65	gold quality
body of uterus	UBERON:0009853	79.25	gold quality
heart right ventricle	UBERON:0002080	78.02	gold quality
gastrocnemius	UBERON:0001388	77.69	gold quality
muscle of leg	UBERON:0001383	77.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LINC00702 was a potential prognostic biomarker for malignant meningioma patients and might exert oncogenic function in the progression of malignant meningioma (PMID:30849635)
• LINC00702 accelerates the progression of ovarian cancer through interacting with EZH2 to inhibit the transcription of KLF2. (PMID:31389610)
• Linc00702 inhibits cell growth and metastasis through regulating PTEN in colorectal cancer. (PMID:32329837)
• LINC00702-mediated DUSP1 transcription in the prevention of bladder cancer progression: Implications in cancer cell proliferation and tumor inflammatory microenvironment. (PMID:35809838)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.