LINC00844

Summary

LINC00844 (long intergenic non-protein coding RNA 844, HGNC:45031) is a long non-coding RNA gene on chromosome 10q21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45031
Approved symbol	LINC00844
Name	long intergenic non-protein coding RNA 844
Location	10q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237949
Ensembl biotype	lncRNA
Entrez	100507008
RNAcentral	URS000075D3C8 — lncRNA, 659 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000432535, ENST00000653466, ENST00000654311, ENST00000657547, ENST00000657805, ENST00000660129, ENST00000660389, ENST00000661129, ENST00000661278, ENST00000661888, ENST00000666160, ENST00000666624, ENST00000667734, ENST00000669076, ENST00000819485, ENST00000819486

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432535 — 2 exons

Exon	Start	End
ENSE00001633954	58999626	58999787
ENSE00001755425	59001229	59001543

Expression profiles

Bgee: expression breadth ubiquitous, 194 present calls, max score 99.47.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 2.7312 / max 398.1724, expressed in 121 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105016	1.8947	114
105013	0.6026	80
105015	0.1762	62
105014	0.0577	30

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lateral globus pallidus	UBERON:0002476	99.47	gold quality
globus pallidus	UBERON:0001875	99.27	gold quality
medial globus pallidus	UBERON:0002477	99.20	gold quality
inferior vagus X ganglion	UBERON:0005363	98.74	gold quality
substantia nigra	UBERON:0002038	98.73	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.66	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.55	gold quality
midbrain	UBERON:0001891	98.52	gold quality
spinal cord	UBERON:0002240	98.52	gold quality
putamen	UBERON:0001874	98.28	gold quality
subthalamic nucleus	UBERON:0001906	98.17	gold quality
substantia nigra pars compacta	UBERON:0001965	97.99	gold quality
medulla oblongata	UBERON:0001896	97.94	gold quality
amygdala	UBERON:0001876	97.93	gold quality
ventral tegmental area	UBERON:0002691	97.74	gold quality
hypothalamus	UBERON:0001898	97.71	gold quality
superior vestibular nucleus	UBERON:0007227	97.69	gold quality
dorsal plus ventral thalamus	UBERON:0001897	97.68	gold quality
pons	UBERON:0000988	97.11	gold quality
caudate nucleus	UBERON:0001873	96.95	gold quality
Ammon’s horn	UBERON:0001954	96.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	96.41	gold quality
nucleus accumbens	UBERON:0001882	96.36	gold quality
corpus callosum	UBERON:0002336	96.25	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.90	gold quality
lateral nuclear group of thalamus	UBERON:0002736	95.66	gold quality
right lobe of liver	UBERON:0001114	94.96	gold quality
temporal lobe	UBERON:0001871	94.01	gold quality
right frontal lobe	UBERON:0002810	93.94	gold quality
endothelial cell	CL:0000115	93.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The expression of LINC00844 is higher in normal prostate compared with malignant and metastatic prostate cancer tumors, and patients with low expression had a poor prognosis, suggesting LINC00844 functions in suppressing tumor progression and metastasis. Further highlights the function of the LINC00844 in regulating global AR-regulated genes in prostate cancer by modulating AR binding to chromatin. (PMID:30115758)
• Long intergenic noncoding RNA 00844 promotes apoptosis and represses proliferation of prostate cancer cells through upregulating GSTP1 by recruiting EBF1. (PMID:32329523)
• LINC00844 suppresses tumor progression and predicts survival outcomes through inhibiting miR-19a-5p in cholangiocarcinoma. (PMID:37400667)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.