LINC00847

Summary

LINC00847 (long intergenic non-protein coding RNA 847, HGNC:45050) is a long non-coding RNA gene on chromosome 5q35.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45050
Approved symbol	LINC00847
Name	long intergenic non-protein coding RNA 847
Location	5q35.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245060
Ensembl biotype	lncRNA
Entrez	729678
RNAcentral	URS000075EC28 — lncRNA, 1894 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 39 lncRNA

ENST00000501855, ENST00000501937, ENST00000502162, ENST00000508309, ENST00000509921, ENST00000651233, ENST00000652659, ENST00000653411, ENST00000653584, ENST00000654313, ENST00000657229, ENST00000658025, ENST00000658585, ENST00000659497, ENST00000659553, ENST00000660674, ENST00000661298, ENST00000661444, ENST00000661810, ENST00000662722, ENST00000665473, ENST00000667360, ENST00000751568, ENST00000751569, ENST00000751570, ENST00000751571, ENST00000751572, ENST00000751573, ENST00000751574, ENST00000751575, ENST00000751576, ENST00000751577, ENST00000751578, ENST00000751579, ENST00000751580, ENST00000751581, ENST00000751582, ENST00000751583, ENST00000751584

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000501855 — 3 exons

Exon	Start	End
ENSE00001977720	180834312	180835726
ENSE00001983743	180831759	180831941
ENSE00002063979	180830957	180831229

Expression profiles

Bgee: expression breadth ubiquitous, 194 present calls, max score 91.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.9234 / max 296.8829, expressed in 1735 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60659	6.8349	1476
60660	6.7564	1694
60658	1.3042	576
60656	0.4644	69
60661	0.4139	208
60655	0.0867	27
60657	0.0629	28

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	91.59	gold quality
left lobe of thyroid gland	UBERON:0001120	89.65	gold quality
right lobe of thyroid gland	UBERON:0001119	89.33	gold quality
thyroid gland	UBERON:0002046	88.54	gold quality
spinal cord	UBERON:0002240	88.23	gold quality
colonic epithelium	UBERON:0000397	87.65	gold quality
granulocyte	CL:0000094	87.04	gold quality
adenohypophysis	UBERON:0002196	86.67	gold quality
spleen	UBERON:0002106	86.07	gold quality
omental fat pad	UBERON:0010414	85.75	gold quality
peritoneum	UBERON:0002358	85.67	gold quality
pituitary gland	UBERON:0000007	85.26	gold quality
tibial nerve	UBERON:0001323	85.23	gold quality
adipose tissue of abdominal region	UBERON:0007808	85.07	gold quality
left ovary	UBERON:0002119	84.95	gold quality
lymph node	UBERON:0000029	84.89	gold quality
leukocyte	CL:0000738	84.77	gold quality
hypothalamus	UBERON:0001898	84.63	gold quality
right coronary artery	UBERON:0001625	84.56	gold quality
monocyte	CL:0000576	84.45	gold quality
apex of heart	UBERON:0002098	84.39	gold quality
islet of Langerhans	UBERON:0000006	84.33	gold quality
right uterine tube	UBERON:0001302	84.25	gold quality
right ovary	UBERON:0002118	83.97	gold quality
caudate nucleus	UBERON:0001873	83.85	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.85	gold quality
nucleus accumbens	UBERON:0001882	83.78	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.73	gold quality
body of pancreas	UBERON:0001150	83.71	gold quality
subcutaneous adipose tissue	UBERON:0002190	83.70	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	5.56
E-ANND-3	yes	3.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LncRNA LINC00847 contributes to hepatocellular carcinoma progression by acting as a sponge of miR-99a to induce E2F2 expression. (PMID:33426857)
• Expression of LINC00847 in Peripheral Blood Mononuclear Cells of Children with Asthma and Its Prediction between Asthma Exacerbation and Remission. (PMID:35356750)
• Long intergenic non-protein coding RNA 847 promotes laryngeal squamous cell carcinoma progression through the microRNA-181a-5p/zinc finger E-box binding homeobox 2 axis. (PMID:35435130)
• Aberrantly Expressed lncRNA LINC00847 May Serve as a Promising Prognostic Factor for Thyroid Cancer. (PMID:37493640)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.