LINC00853

Summary

LINC00853 (long intergenic non-protein coding RNA 853, HGNC:43716) is a long non-coding RNA gene on chromosome 1p33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43716
Approved symbol	LINC00853
Name	long intergenic non-protein coding RNA 853
Location	1p33
Locus type	RNA, long non-coding
Status	Approved
Aliases	ncRNA-a4
Ensembl gene	ENSG00000224805
Ensembl biotype	lncRNA
Entrez	100874253
RNAcentral	URS000075C27B — lncRNA, 669 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000429328, ENST00000816024, ENST00000816025, ENST00000816026, ENST00000816027, ENST00000816028, ENST00000816029, ENST00000816030, ENST00000816031

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429328 — 2 exons

Exon	Start	End
ENSE00001610036	47179868	47180339
ENSE00001725217	47179250	47179438

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 88.89.

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.89	gold quality
monocyte	CL:0000576	86.01	gold quality
leukocyte	CL:0000738	84.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.03	silver quality
kidney epithelium	UBERON:0004819	75.34	gold quality
granulocyte	CL:0000094	72.78	gold quality
adult mammalian kidney	UBERON:0000082	72.06	gold quality
cortical plate	UBERON:0005343	65.56	gold quality
kidney	UBERON:0002113	64.86	gold quality
blood	UBERON:0000178	64.17	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	64.09	gold quality
bone marrow cell	CL:0002092	63.94	silver quality
amygdala	UBERON:0001876	63.33	gold quality
epithelial cell of pancreas	CL:0000083	62.78	gold quality
tendon of biceps brachii	UBERON:0008188	62.44	gold quality
cortex of kidney	UBERON:0001225	62.36	gold quality
metanephros cortex	UBERON:0010533	62.35	gold quality
anterior cingulate cortex	UBERON:0009835	61.67	gold quality
putamen	UBERON:0001874	61.13	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.45	gold quality
mucosa of transverse colon	UBERON:0004991	60.36	gold quality
ganglionic eminence	UBERON:0004023	60.15	gold quality
right lobe of liver	UBERON:0001114	60.07	gold quality
right frontal lobe	UBERON:0002810	60.04	gold quality
right lung	UBERON:0002167	59.76	gold quality
rectum	UBERON:0001052	59.57	gold quality
islet of Langerhans	UBERON:0000006	59.33	gold quality
descending thoracic aorta	UBERON:0002345	59.15	gold quality
left adrenal gland cortex	UBERON:0035825	59.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Serum small extracellular vesicle-derived LINC00853 as a novel diagnostic marker for early hepatocellular carcinoma. (PMID:32525601)
• LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25. (PMID:34808497)
• Systemic Analyses of Cuproptosis-Related lncRNAs in Pancreatic Adenocarcinoma, with a Focus on the Molecular Mechanism of LINC00853. (PMID:37175629)
• Overexpression of LINC00853 enhances tumorigenesis and metastasis of gastric cancer. (PMID:38171082)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.