LINC00857

Summary

LINC00857 (long intergenic non-protein coding RNA 857, HGNC:45114) is a long non-coding RNA gene on chromosome 10q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45114
Approved symbol	LINC00857
Name	long intergenic non-protein coding RNA 857
Location	10q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	HUMT
Ensembl gene	ENSG00000237523
Ensembl biotype	lncRNA
Entrez	439990
RNAcentral	URS000075AEB1 — lncRNA, 2171 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000422847, ENST00000432308, ENST00000660450, ENST00000671081, ENST00000819791, ENST00000819792, ENST00000819793, ENST00000819794, ENST00000819795, ENST00000819796, ENST00000819797, ENST00000819798, ENST00000819799, ENST00000819800

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422847 — 2 exons

Exon	Start	End
ENSE00001788315	80207710	80208231
ENSE00004225066	80218019	80219657

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 79.32.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2316 / max 30.4134, expressed in 653 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105848	0.7961	487
105847	0.3541	200
105849	0.0815	31

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	79.32	gold quality
buccal mucosa cell	CL:0002336	76.84	silver quality
colonic epithelium	UBERON:0000397	75.24	gold quality
islet of Langerhans	UBERON:0000006	70.16	gold quality
ascending aorta	UBERON:0001496	70.01	gold quality
thoracic aorta	UBERON:0001515	69.93	gold quality
descending thoracic aorta	UBERON:0002345	68.62	gold quality
smooth muscle tissue	UBERON:0001135	68.17	gold quality
duodenum	UBERON:0002114	68.04	gold quality
stromal cell of endometrium	CL:0002255	67.98	gold quality
mucosa of transverse colon	UBERON:0004991	67.41	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.07	gold quality
right coronary artery	UBERON:0001625	66.90	gold quality
lower esophagus	UBERON:0013473	66.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.53	gold quality
gall bladder	UBERON:0002110	66.37	gold quality
rectum	UBERON:0001052	65.98	gold quality
aorta	UBERON:0000947	65.14	gold quality
left uterine tube	UBERON:0001303	65.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.88	gold quality
endocervix	UBERON:0000458	64.82	gold quality
small intestine	UBERON:0002108	64.66	gold quality
esophagus	UBERON:0001043	64.56	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.46	gold quality
left ovary	UBERON:0002119	64.33	gold quality
ectocervix	UBERON:0012249	64.32	gold quality
left coronary artery	UBERON:0001626	63.84	gold quality
transverse colon	UBERON:0001157	63.77	gold quality
body of uterus	UBERON:0009853	63.54	gold quality
jejunal mucosa	UBERON:0000399	63.37	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.09

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Overexpression of LINC00857 increased cancer cell proliferation, colony formation and invasion. Mechanistic analyses indicated that LINC00857 mediates tumor progression via cell cycle regulation. (PMID:26862852)
• Long non-coding RNA HUMT hypomethylation promotes lymphangiogenesis and metastasis via activating FOXK1 transcription in triple-negative breast cancer. (PMID:32138762)
• LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway. (PMID:32918541)
• LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma. (PMID:33657224)
• LncRNA LINC00857 strengthens the malignancy behaviors of pancreatic adenocarcinoma cells by serving as a competing endogenous RNA for miR-340-5p to upregulate TGFA expression. (PMID:33661995)
• LINC00857 promotes colorectal cancer progression by sponging miR-150-5p and upregulating HMGB3 (high mobility group box 3) expression. (PMID:34753396)
• Knockdown of long noncoding RNA HUMT inhibits the proliferation and metastasis by regulating miR-455-5p/LRP4 axis in hepatocellular carcinoma. (PMID:35293286)
• Oncogenic LINC00857 recruits TFAP2C to elevate FAT1 expression in gastric cancer. (PMID:35524544)
• Regulation of Transcription Factor YAP-TEAD by Non-coding RNA LINC00857 and the Inhibitory Effects on Ovarian Cancer Cell Proliferation. (PMID:35869712)
• Mutant p53 driven-LINC00857, a protein scaffold between FOXM1 and deubiquitinase OTUB1, promotes the metastasis of pancreatic cancer. (PMID:36272615)
• Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis. (PMID:37378889)
• Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis. (PMID:38721812)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.