LINC00858

Summary

LINC00858 (long intergenic non-protein coding RNA 858, HGNC:27276) is a long non-coding RNA gene on chromosome 10q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27276
Approved symbol	LINC00858
Name	long intergenic non-protein coding RNA 858
Location	10q23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	CRCAL-2, LNMAT2
Ensembl gene	ENSG00000229404
Ensembl biotype	lncRNA
Entrez	170425
RNAcentral	URS00004F6E74 — lncRNA, 2685 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 20 lncRNA

ENST00000415469, ENST00000437892, ENST00000653603, ENST00000661042, ENST00000661556, ENST00000661758, ENST00000663433, ENST00000666427, ENST00000669640, ENST00000817596, ENST00000817597, ENST00000817598, ENST00000817599, ENST00000817600, ENST00000817601, ENST00000817602, ENST00000817603, ENST00000817604, ENST00000817605, ENST00000817606

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415469 — 6 exons

Exon	Start	End
ENSE00001603240	84288594	84288780
ENSE00001611463	84293246	84294659
ENSE00001640791	84288975	84289044
ENSE00001646514	84288224	84288420
ENSE00001651131	84291407	84292137
ENSE00001666007	84279980	84280065

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 72.20.

Top tissues by expression

198 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.20	gold quality
ganglionic eminence	UBERON:0004023	61.01	gold quality
nasal cavity epithelium	UBERON:0005384	54.06	gold quality
prefrontal cortex	UBERON:0000451	49.95	gold quality
monocyte	CL:0000576	49.75	silver quality
rectum	UBERON:0001052	49.03	gold quality
sperm	CL:0000019	48.58	gold quality
islet of Langerhans	UBERON:0000006	48.41	gold quality
muscle of leg	UBERON:0001383	48.26	silver quality
lymph node	UBERON:0000029	47.81	gold quality
deltoid	UBERON:0001476	47.67	gold quality
fundus of stomach	UBERON:0001160	47.38	gold quality
gastrocnemius	UBERON:0001388	47.25	silver quality
cortex of kidney	UBERON:0001225	47.07	gold quality
gall bladder	UBERON:0002110	46.72	gold quality
placenta	UBERON:0001987	46.70	gold quality
body of stomach	UBERON:0001161	46.59	gold quality
lateral globus pallidus	UBERON:0002476	46.23	gold quality
stomach	UBERON:0000945	46.21	gold quality
duodenum	UBERON:0002114	45.87	gold quality
mucosa of transverse colon	UBERON:0004991	45.75	gold quality
Brodmann (1909) area 9	UBERON:0013540	45.71	silver quality
pancreas	UBERON:0001264	45.60	gold quality
metanephros cortex	UBERON:0010533	45.53	gold quality
body of pancreas	UBERON:0001150	45.30	gold quality
body of uterus	UBERON:0009853	44.82	gold quality
right atrium auricular region	UBERON:0006631	44.55	gold quality
transverse colon	UBERON:0001157	44.45	gold quality
ectocervix	UBERON:0012249	44.45	gold quality
nasal cavity mucosa	UBERON:0001826	44.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 17)

• we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in non-small cell lung cancer (NSCLC). Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. In NSCLC patients, high expression of LINC00858 closely correlated with tumor progression. (PMID:28177876)
• Long non-coding RNA LINC00858 promotes cells proliferation, migration and invasion by acting as a ceRNA of miR-22-3p in colorectal cancer (PMID:30931636)
• linc00858 acted as a competitive endogenous RNA to sponged miR-3182 and regulate MMP2 in lung cancer (PMID:31131637)
• Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4alpha and WNK2 regulation. (PMID:31884577)
• Up-regulation of long noncoding RNA LINC00858 is associated with poor prognosis in gastric cancer. (PMID:32119160)
• Long noncoding RNA LINC00858 promotes TP53wildtype colorectal cancer progression by regulating the microRNA253p/SMAD7 axis. (PMID:32323793)
• LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation. (PMID:32447640)
• LINC00858 facilitates the malignant development of Wilms’ Tumor by targeting miR-653-5p. (PMID:32538587)
• Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation. (PMID:32768499)
• Long non-coding RNA LINC00858 aggravates the oncogenic phenotypes of ovarian cancer cells through miR-134-5p/RAD18 signaling. (PMID:32875345)
• Long non-coding RNA LINC00858 promotes cells proliferation and invasion through the miR-153-3p/Rabl3 axis in hepatocellular carcinoma. (PMID:33015775)
• Long noncoding RNA LINC00858 promotes the proliferation, migration and invasion of gastric cancer cells via the miR-363-3p/FOXP4 axis. (PMID:33015780)
• Up-regulated lncRNA LINC00858 facilitates proliferation and migration of gastric cancer cells. (PMID:33112114)
• Long noncoding RNA 00858 knockdown alleviates bladder cancer via regulation of the miR30645p/CTGF axis. (PMID:34132366)
• Long noncoding RNA LINC00858 promotes the progression of ovarian cancer via regulating the miR-134-5p/TRIM44 axis. (PMID:34423728)
• LINC00858 facilitates formation of hepatic metastases from colorectal cancer via regulating the miR-132-3p/IGF2BP1 axis. (PMID:36857196)
• Long intergenic non-protein coding RNA 00858 participates in the occurrence and development of esophageal squamous cell carcinoma through the activation of the FTO-m6A-MYC axis by recruiting ZNF184. (PMID:36868327)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.