LINC00880

Summary

LINC00880 (long intergenic non-protein coding RNA 880, HGNC:27948) is a long non-coding RNA gene on chromosome 3q25.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27948
Approved symbol	LINC00880
Name	long intergenic non-protein coding RNA 880
Location	3q25.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000243629
Ensembl biotype	lncRNA
Entrez	339894
RNAcentral	URS000075C6E4 — lncRNA, 2016 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000471357, ENST00000659739, ENST00000782045

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000471357 — 4 exons

Exon	Start	End
ENSE00001809679	157101935	157102092
ENSE00001879700	157081667	157083275
ENSE00001898671	157122876	157123004
ENSE00002525893	157103358	157103479

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 74.33.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2285 / max 57.1101, expressed in 65 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
45276	0.2285	65

Top tissues by expression

218 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.33	gold quality
adenohypophysis	UBERON:0002196	64.67	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.03	gold quality
pituitary gland	UBERON:0000007	60.85	gold quality
ventricular zone	UBERON:0003053	60.77	gold quality
cortical plate	UBERON:0005343	60.26	silver quality
leukocyte	CL:0000738	59.70	silver quality
stromal cell of endometrium	CL:0002255	58.88	gold quality
endothelial cell	CL:0000115	58.23	gold quality
corpus callosum	UBERON:0002336	56.85	gold quality
ganglionic eminence	UBERON:0004023	56.24	silver quality
lymph node	UBERON:0000029	55.60	gold quality
buccal mucosa cell	CL:0002336	54.11	gold quality
oocyte	CL:0000023	51.35	gold quality
hypothalamus	UBERON:0001898	50.92	gold quality
right atrium auricular region	UBERON:0006631	50.65	gold quality
cardiac atrium	UBERON:0002081	50.35	gold quality
heart left ventricle	UBERON:0002084	50.30	gold quality
vermiform appendix	UBERON:0001154	49.69	gold quality
muscle of leg	UBERON:0001383	49.61	gold quality
cardiac ventricle	UBERON:0002082	49.60	gold quality
islet of Langerhans	UBERON:0000006	49.54	gold quality
gastrocnemius	UBERON:0001388	49.46	gold quality
endocervix	UBERON:0000458	49.39	gold quality
caudate nucleus	UBERON:0001873	49.27	gold quality
blood	UBERON:0000178	49.18	gold quality
heart	UBERON:0000948	49.08	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.68	gold quality
right testis	UBERON:0004534	48.66	gold quality
body of uterus	UBERON:0009853	48.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.83

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma. (PMID:37620336)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.