LINC00885

Summary

LINC00885 (long intergenic non-protein coding RNA 885, HGNC:48571) is a long non-coding RNA gene on chromosome 3q29.

Implicated in cervical cancer. Biomarker of cervical cancer.

Source: NCBI Gene 401109 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48571
Approved symbol	LINC00885
Name	long intergenic non-protein coding RNA 885
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Aliases	PARylator
Ensembl gene	ENSG00000224652
Ensembl biotype	lncRNA
Entrez	401109
RNAcentral	URS000044FC51 — lncRNA, 1828 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 47 — 47 lncRNA

ENST00000457079, ENST00000654470, ENST00000659409, ENST00000662113, ENST00000662916, ENST00000669905, ENST00000670584, ENST00000687908, ENST00000689269, ENST00000702140, ENST00000744814, ENST00000744815, ENST00000744816, ENST00000744817, ENST00000744818, ENST00000744819, ENST00000744820, ENST00000744821, ENST00000744822, ENST00000744823, ENST00000744824, ENST00000744825, ENST00000744826, ENST00000744827, ENST00000744828, ENST00000744829, ENST00000744830, ENST00000744831, ENST00000744832, ENST00000744833, ENST00000744834, ENST00000744835, ENST00000744836, ENST00000744837, ENST00000744838, ENST00000744839, ENST00000744840, ENST00000744841, ENST00000744842, ENST00000744843, ENST00000744844, ENST00000744845, ENST00000744846, ENST00000744847, ENST00000744848, ENST00000744849, ENST00000744850

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000457079 — 3 exons

Exon	Start	End
ENSE00001697228	196143906	196144377
ENSE00004084145	196142513	196143000
ENSE00004084190	196159900	196160895

Expression profiles

Bgee: expression breadth broad, 87 present calls, max score 92.61.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5384 / max 38.7892, expressed in 227 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40711	0.2017	120
203075	0.1432	86
203076	0.0989	66
40710	0.0946	42

Top tissues by expression

87 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.61	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.67	gold quality
placenta	UBERON:0001987	70.08	gold quality
skin of abdomen	UBERON:0001416	69.20	gold quality
zone of skin	UBERON:0000014	67.94	gold quality
liver	UBERON:0002107	67.01	gold quality
skin of leg	UBERON:0001511	66.99	gold quality
esophagus mucosa	UBERON:0002469	66.53	gold quality
anterior cingulate cortex	UBERON:0009835	66.51	gold quality
esophagus	UBERON:0001043	66.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.14	gold quality
right lobe of liver	UBERON:0001114	65.30	gold quality
saliva-secreting gland	UBERON:0001044	64.50	gold quality
minor salivary gland	UBERON:0001830	64.42	gold quality
ganglionic eminence	UBERON:0004023	61.65	gold quality
kidney	UBERON:0002113	60.67	gold quality
adult mammalian kidney	UBERON:0000082	60.55	gold quality
lower esophagus mucosa	UBERON:0035834	60.30	gold quality
vagina	UBERON:0000996	60.16	gold quality
prostate gland	UBERON:0002367	60.16	gold quality
left ovary	UBERON:0002119	60.05	gold quality
urinary bladder	UBERON:0001255	59.72	gold quality
tonsil	UBERON:0002372	59.50	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.50	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.25	gold quality
multicellular organism	UBERON:0000468	58.62	gold quality
thoracic mammary gland	UBERON:0005200	58.09	gold quality
cortex of kidney	UBERON:0001225	57.43	gold quality
blood	UBERON:0000178	56.44	gold quality
ectocervix	UBERON:0012249	55.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LINC00885 a Novel Oncogenic Long Non-Coding RNA Associated with Early Stage Breast Cancer Progression. (PMID:33049922)
• LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A. (PMID:35012615)
• LncRNA LINC00885 promotes bladder cancer progression by targeting the miR-98-5p/PBX3 axis. (PMID:37300672)
• Long noncoding RNA LINC00885 upregulates NCK1 to promote cell viability and migration of triple-negative breast cancer cells through sponging miR-654-3p. (PMID:37694355)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.