LINC00887

Summary

LINC00887 (long intergenic non-protein coding RNA 887, HGNC:48574) is a long non-coding RNA gene on chromosome 3q29.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48574
Approved symbol	LINC00887
Name	long intergenic non-protein coding RNA 887
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-ATP13A4-8, HEIRCC, ACLY-BP
Ensembl gene	ENSG00000214145
Ensembl biotype	lncRNA
Entrez	100131551
RNAcentral	URS000075A9B0 — lncRNA, 3021 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 48 — 48 lncRNA

ENST00000397644, ENST00000414120, ENST00000415869, ENST00000429578, ENST00000432908, ENST00000456816, ENST00000653788, ENST00000654010, ENST00000654752, ENST00000657249, ENST00000658228, ENST00000659219, ENST00000660996, ENST00000662346, ENST00000662552, ENST00000664894, ENST00000666638, ENST00000667386, ENST00000669998, ENST00000670716, ENST00000670959, ENST00000686489, ENST00000715829, ENST00000794664, ENST00000794665, ENST00000794666, ENST00000794667, ENST00000794668, ENST00000794669, ENST00000794670, ENST00000794671, ENST00000794672, ENST00000794673, ENST00000794674, ENST00000794675, ENST00000794676, ENST00000794677, ENST00000794678, ENST00000794679, ENST00000794680, ENST00000794681, ENST00000794682, ENST00000794683, ENST00000794684, ENST00000794686, ENST00000794687, ENST00000794688, ENST00000794689

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000397644 — 2 exons

Exon	Start	End
ENSE00001607257	194301446	194301586
ENSE00001785616	194305757	194306031

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 91.35.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6625 / max 72.4868, expressed in 203 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46196	0.4109	150
46195	0.0732	37
46190	0.0694	20
46194	0.0521	26
46191	0.0452	8
46192	0.0116	5

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland cortex	UBERON:0035825	91.35	gold quality
left adrenal gland	UBERON:0001234	91.29	gold quality
right adrenal gland	UBERON:0001233	90.19	gold quality
right adrenal gland cortex	UBERON:0035827	89.33	gold quality
adrenal cortex	UBERON:0001235	88.60	gold quality
adrenal gland	UBERON:0002369	85.69	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.03	silver quality
lower esophagus mucosa	UBERON:0035834	78.27	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.52	gold quality
esophagus mucosa	UBERON:0002469	70.71	gold quality
buccal mucosa cell	CL:0002336	68.48	gold quality
ectocervix	UBERON:0012249	64.11	gold quality
right testis	UBERON:0004534	63.96	gold quality
smooth muscle tissue	UBERON:0001135	63.77	gold quality
vagina	UBERON:0000996	63.53	gold quality
gall bladder	UBERON:0002110	62.81	gold quality
esophagus	UBERON:0001043	61.51	gold quality
cortex of kidney	UBERON:0001225	60.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.70	gold quality
ganglionic eminence	UBERON:0004023	60.61	gold quality
left testis	UBERON:0004533	60.40	gold quality
islet of Langerhans	UBERON:0000006	60.18	gold quality
testis	UBERON:0000473	59.47	gold quality
uterine cervix	UBERON:0000002	59.39	gold quality
left ovary	UBERON:0002119	59.06	gold quality
sural nerve	UBERON:0015488	57.85	silver quality
right ovary	UBERON:0002118	56.04	gold quality
minor salivary gland	UBERON:0001830	55.97	gold quality
ovary	UBERON:0000992	55.75	gold quality
endocervix	UBERON:0000458	55.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Elevated expression of the long non-coding RNA HEIRCC in renal cell carcinoma cells promotes epithelial-mesenchymal transition and neoplasm metastasis. (PMID:28030807)
• suggested that LINC00887 can stimulate miR613, miR206 and miR12 to become competing endogenous RNAs (PMID:31322230)
• Serum long non-coding RNA LINC00887 as a potential biomarker for diagnosis of renal cell carcinoma. (PMID:32654370)
• LINC00887 regulates the proliferation of nasopharyngeal carcinoma via targeting miRNA-203b-3p to upregulate NUP205. (PMID:32964975)
• LINC00887 aggravates the malignant progression of glioma via upregulating CCND1. (PMID:33660802)
• A pair of long intergenic non-coding RNA LINC00887 variants act antagonistically to control Carbonic Anhydrase IX transcription upon hypoxia in tongue squamous carcinoma progression. (PMID:34493285)
• LINC00887 Fosters Development of Clear Cell Renal Cell Carcinoma via Inhibiting CD8+ T Cell Immune Infiltration. (PMID:36060659)
• Delving into the Role of lncRNAs in Papillary Thyroid Cancer: Upregulation of LINC00887 Promotes Cell Proliferation, Growth and Invasion. (PMID:38338866)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.