LINC00921

Summary

LINC00921 (long intergenic non-protein coding RNA 921, HGNC:26830) is a long non-coding RNA gene on chromosome 16p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26830
Approved symbol	LINC00921
Name	long intergenic non-protein coding RNA 921
Location	16p13.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ39639
Ensembl gene	ENSG00000281005
Ensembl biotype	lncRNA
Entrez	283876
RNAcentral	URS000075AD3E — lncRNA, 2443 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000572123, ENST00000573951, ENST00000706009

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000572123 — 3 exons

Exon	Start	End
ENSE00002661182	3265666	3265768
ENSE00002675838	3267126	3267181
ENSE00003766422	3263800	3263883

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 80.08.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2406 / max 150.0727, expressed in 592 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
152411	2.8462	770
152410	1.1599	405
152413	0.5243	60
152409	0.3903	188
152412	0.1662	72

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	80.08	gold quality
bone marrow cell	CL:0002092	77.05	gold quality
granulocyte	CL:0000094	76.81	gold quality
leukocyte	CL:0000738	76.27	gold quality
monocyte	CL:0000576	76.12	gold quality
blood	UBERON:0000178	75.00	gold quality
spleen	UBERON:0002106	72.25	gold quality
mucosa of stomach	UBERON:0001199	71.84	gold quality
endocervix	UBERON:0000458	71.67	gold quality
left ovary	UBERON:0002119	70.91	gold quality
oviduct epithelium	UBERON:0004804	70.07	silver quality
lower esophagus muscularis layer	UBERON:0035833	69.72	gold quality
lower esophagus	UBERON:0013473	69.68	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.39	gold quality
body of uterus	UBERON:0009853	69.27	gold quality
right coronary artery	UBERON:0001625	68.67	gold quality
left coronary artery	UBERON:0001626	68.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.38	gold quality
epithelial cell of pancreas	CL:0000083	68.11	gold quality
popliteal artery	UBERON:0002250	67.79	gold quality
tibial artery	UBERON:0007610	67.79	gold quality
vagina	UBERON:0000996	67.55	gold quality
right ovary	UBERON:0002118	67.47	gold quality
tibial nerve	UBERON:0001323	67.46	gold quality
right lung	UBERON:0002167	67.27	gold quality
coronary artery	UBERON:0001621	66.99	gold quality
ectocervix	UBERON:0012249	66.90	gold quality
lymph node	UBERON:0000029	66.89	gold quality
minor salivary gland	UBERON:0001830	66.80	gold quality
sural nerve	UBERON:0015488	66.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation. (PMID:37999979)
• Long noncoding RNA LINC00921 serves as a predictive biomarker for lung adenocarcinoma: An observational study. (PMID:38363898)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.