LINC00922

Summary

LINC00922 (long intergenic non-protein coding RNA 922, HGNC:27545) is a long non-coding RNA gene on chromosome 16q21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27545
Approved symbol	LINC00922
Name	long intergenic non-protein coding RNA 922
Location	16q21
Locus type	RNA, long non-coding
Status	Approved
Aliases	Lnc-LALC
Ensembl gene	ENSG00000261742
Ensembl biotype	lncRNA
Entrez	283867
RNAcentral	URS00025E34D2 — lncRNA, 1754 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000564041, ENST00000568492, ENST00000569736, ENST00000656349, ENST00000662702, ENST00000663762, ENST00000663867, ENST00000663911, ENST00000764686, ENST00000764687, ENST00000764688, ENST00000764689, ENST00000764690, ENST00000764691, ENST00000764692, ENST00000764693

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000564041 — 10 exons

Exon	Start	End
ENSE00002499269	65375204	65375326
ENSE00002589551	65285024	65285439
ENSE00002596857	65363663	65363808
ENSE00002597013	65311414	65311547
ENSE00002598844	65372233	65372269
ENSE00002610181	65571771	65571789
ENSE00002613818	65371036	65371204
ENSE00002614675	65363211	65363291
ENSE00002617707	65354243	65354301
ENSE00002622085	65356431	65356489

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 62.22.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0312 / max 10.0353, expressed in 13 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157682	0.0312	13

Top tissues by expression

192 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	62.22	gold quality
ganglionic eminence	UBERON:0004023	61.93	gold quality
cerebellar vermis	UBERON:0004720	58.50	gold quality
esophagus squamous epithelium	UBERON:0006920	58.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.10	gold quality
bone marrow	UBERON:0002371	56.99	gold quality
mucosa of paranasal sinus	UBERON:0005030	55.40	gold quality
upper lobe of left lung	UBERON:0008952	55.40	gold quality
tibia	UBERON:0000979	55.24	gold quality
trabecular bone tissue	UBERON:0002483	55.03	gold quality
oral cavity	UBERON:0000167	54.50	gold quality
upper lobe of lung	UBERON:0008948	53.78	gold quality
germinal epithelium of ovary	UBERON:0001304	53.56	gold quality
biceps brachii	UBERON:0001507	52.97	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	52.53	gold quality
right lobe of thyroid gland	UBERON:0001119	52.45	gold quality
lung	UBERON:0002048	52.42	gold quality
pigmented layer of retina	UBERON:0001782	52.22	gold quality
metanephros	UBERON:0000081	52.13	gold quality
cartilage tissue	UBERON:0002418	52.05	gold quality
stromal cell of endometrium	CL:0002255	51.49	silver quality
nasal cavity epithelium	UBERON:0005384	51.44	gold quality
spleen	UBERON:0002106	51.33	gold quality
islet of Langerhans	UBERON:0000006	50.76	gold quality
gall bladder	UBERON:0002110	50.27	gold quality
prefrontal cortex	UBERON:0000451	49.79	gold quality
pancreas	UBERON:0001264	49.79	gold quality
liver	UBERON:0002107	49.53	gold quality
calcaneal tendon	UBERON:0003701	49.39	silver quality
sperm	CL:0000019	48.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation. (PMID:33045317)
• Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1. (PMID:33637680)
• LINC00922 promotes the proliferation, migration, invasion and EMT process of liver cancer cells by regulating miR-424-5p/ARK5. (PMID:34097192)
• LINC00922 promotes deterioration of gastric cancer. (PMID:35511773)
• LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter. (PMID:37789393)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.