LINC00943

Summary

LINC00943 (long intergenic non-protein coding RNA 943, HGNC:48639) is a long non-coding RNA gene on chromosome 12q24.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48639
Approved symbol	LINC00943
Name	long intergenic non-protein coding RNA 943
Location	12q24.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000189238
Ensembl biotype	lncRNA
Entrez	100507206
RNAcentral	URS000075E332 — lncRNA, 2261 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 92 — 92 lncRNA

ENST00000345111, ENST00000535118, ENST00000535544, ENST00000537374, ENST00000539315, ENST00000540250, ENST00000541359, ENST00000616373, ENST00000653920, ENST00000654123, ENST00000654173, ENST00000654558, ENST00000655433, ENST00000656138, ENST00000656166, ENST00000656659, ENST00000656695, ENST00000658458, ENST00000659292, ENST00000659340, ENST00000659485, ENST00000659587, ENST00000660082, ENST00000660396, ENST00000660709, ENST00000661264, ENST00000661435, ENST00000661679, ENST00000662118, ENST00000662393, ENST00000662520, ENST00000663365, ENST00000663771, ENST00000664572, ENST00000665222, ENST00000665596, ENST00000665641, ENST00000665789, ENST00000665976, ENST00000665993, ENST00000666484, ENST00000667256, ENST00000667312, ENST00000667375, ENST00000667490, ENST00000668231, ENST00000668611, ENST00000669031, ENST00000669417, ENST00000669542, ENST00000670225, ENST00000670324, ENST00000670760, ENST00000809764, ENST00000809765, ENST00000809766, ENST00000809767, ENST00000809768, ENST00000809769, ENST00000809770, ENST00000809771, ENST00000809772, ENST00000809773, ENST00000809774, ENST00000809775, ENST00000809776, ENST00000809777, ENST00000809778, ENST00000809779, ENST00000809780, ENST00000809781, ENST00000809782, ENST00000809783, ENST00000809784, ENST00000809785, ENST00000809786, ENST00000809787, ENST00000809788, ENST00000809789, ENST00000809790, ENST00000809791, ENST00000809792, ENST00000809793, ENST00000809794, ENST00000809795, ENST00000809796, ENST00000809797, ENST00000809798, ENST00000809799, ENST00000809800, ENST00000809801, ENST00000809802

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000345111 — 3 exons

Exon	Start	End
ENSE00001377910	126745006	126746236
ENSE00001379901	126744770	126744919
ENSE00001471562	126742736	126743480

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 95.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0185 / max 16.1059, expressed in 4 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128681	0.0146	4
206953	0.0039	2

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	95.69	gold quality
left testis	UBERON:0004533	95.39	gold quality
right testis	UBERON:0004534	94.93	gold quality
ventricular zone	UBERON:0003053	94.60	gold quality
testis	UBERON:0000473	91.52	gold quality
ganglionic eminence	UBERON:0004023	89.83	gold quality
oocyte	CL:0000023	80.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.55	gold quality
bone marrow cell	CL:0002092	75.71	gold quality
secondary oocyte	CL:0000655	75.54	gold quality
granulocyte	CL:0000094	72.86	gold quality
prefrontal cortex	UBERON:0000451	69.64	gold quality
anterior cingulate cortex	UBERON:0009835	69.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.68	gold quality
cortical plate	UBERON:0005343	68.06	gold quality
pancreatic ductal cell	CL:0002079	66.97	silver quality
right frontal lobe	UBERON:0002810	66.72	gold quality
adult organism	UBERON:0007023	65.28	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.99	gold quality
tibialis anterior	UBERON:0001385	64.84	silver quality
neocortex	UBERON:0001950	64.56	gold quality
nasal cavity epithelium	UBERON:0005384	63.60	gold quality
frontal cortex	UBERON:0001870	63.47	gold quality
mucosa of paranasal sinus	UBERON:0005030	63.30	gold quality
germinal epithelium of ovary	UBERON:0001304	62.89	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.54	gold quality
superficial temporal artery	UBERON:0001614	62.34	gold quality
vermiform appendix	UBERON:0001154	61.39	gold quality
cerebral cortex	UBERON:0000956	60.50	gold quality
spleen	UBERON:0002106	60.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Reconstruction of lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveals functional lncRNAs in skin cutaneous melanoma. (PMID:32993558)
• LINC00943 knockdown attenuates MPP(+)-induced neuronal damage via miR-15b-5p/RAB3IP axis in SK-N-SH cells. (PMID:33208053)
• The regulatory effect of lncRNA LINC00943 on the progression of hepatocellular carcinoma and its relationship with clinicopathological features. (PMID:38145786)
• Expression of lncRNA LINC00943 in lung squamous cell carcinoma and its relationship with tumor progression. (PMID:38627774)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.