LINC00958

Summary

LINC00958 (long intergenic non-protein coding RNA 958, HGNC:48671) is a long non-coding RNA gene on chromosome 11p15.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48671
Approved symbol	LINC00958
Name	long intergenic non-protein coding RNA 958
Location	11p15.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000251381
Ensembl biotype	lncRNA
OMIM	618335
Entrez	100506305
RNAcentral	URS000075EDB6 — lncRNA, 1576 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000504230, ENST00000526388, ENST00000527945, ENST00000529328, ENST00000531402, ENST00000532541, ENST00000534477, ENST00000653758, ENST00000653958, ENST00000653981, ENST00000658243, ENST00000662291, ENST00000663902, ENST00000667588, ENST00000671253, ENST00000671577

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000504230 — 2 exons

Exon	Start	End
ENSE00002020901	12979535	12980999
ENSE00002200524	12989456	12989548

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 88.34.

FANTOM5 (CAGE): breadth broad, TPM avg 5.5137 / max 310.9449, expressed in 389 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118717	5.5137	389

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	88.34	gold quality
esophagus mucosa	UBERON:0002469	82.75	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.80	gold quality
cortex of kidney	UBERON:0001225	77.46	gold quality
adult mammalian kidney	UBERON:0000082	76.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.30	gold quality
metanephros cortex	UBERON:0010533	74.34	gold quality
kidney	UBERON:0002113	74.16	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.14	gold quality
skin of abdomen	UBERON:0001416	74.13	gold quality
vena cava	UBERON:0004087	73.19	silver quality
skin of leg	UBERON:0001511	72.85	gold quality
zone of skin	UBERON:0000014	71.22	gold quality
pharyngeal mucosa	UBERON:0000355	70.18	gold quality
tonsil	UBERON:0002372	69.93	gold quality
vagina	UBERON:0000996	69.68	gold quality
sperm	CL:0000019	69.24	gold quality
bone marrow cell	CL:0002092	69.13	silver quality
epithelium of nasopharynx	UBERON:0001951	69.13	silver quality
buccal mucosa cell	CL:0002336	68.87	silver quality
cardia of stomach	UBERON:0001162	68.83	gold quality
saphenous vein	UBERON:0007318	68.77	gold quality
body of tongue	UBERON:0011876	68.75	silver quality
superior surface of tongue	UBERON:0007371	68.54	gold quality
tongue	UBERON:0001723	68.45	silver quality
esophagus	UBERON:0001043	68.41	gold quality
trachea	UBERON:0003126	68.40	silver quality
ventricular zone	UBERON:0003053	68.21	gold quality
renal medulla	UBERON:0000362	68.07	silver quality
pylorus	UBERON:0001166	67.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• Study identified novel long non-coding RNAs LINC00958 and LINC01296 in bladder cancer that likely act as oncogenic drivers contributing to an aggressive cancerous phenotype likely through interaction with proteins involved in initiation of translation and/or post-transcriptional modification of RNA. (PMID:28341852)
• BLACAT2 plays a crucial role in lymphangiogenesis and lymphatic metastasis, and our data highlight a regulatory mechanism for VEGF-C and LN metastasis in bladder cancer (PMID:29355840)
• LINC00958 acts as an oncogenic gene in the gliomagenesis through miR-203-CDK2 regulation, providing a novel insight into glioma tumorigenesis. (PMID:29570358)
• LINC00958 may bind to miR-330-5p to inhibit PAX8 in a competitive fashion, thereby preventing the progression of pancreatic cancer. (PMID:30639194)
• Elevated long non-coding RNA LINC00958 was associated with metastasis and unfavorable prognosis in gastric cancer. (PMID:30720167)
• promotes oral squamous cell carcinoma by sponging miR-185-5p/YWHAZ (PMID:31442551)
• LINC00958 facilitates cervical cancer cell proliferation and metastasis by sponging miR-625-5p to upregulate LRRC8E expression. (PMID:31691355)
• Knockdown of LINC00958 led to impaired proliferation, induced apoptosis, and hampered migration in lung adenocarcinoma cells. LINC00958 exerted the tumor-promoting function in LUAD by enhancing the transactivation of p-c-JUN through activating JNK signaling. (PMID:31855084)
• M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. (PMID:31915027)
• LINC00958 Involves in Bladder Cancer Through Sponging miR-378a-3p to Elevate IGF1R. (PMID:32349525)
• Silencing of long non-coding RNA LINC00958 inhibits head and neck squamous cell carcinoma progression and AKT/mTOR signaling pathway by targeting miR-106a-5p. (PMID:32894548)
• LINC01133 and LINC01243 are positively correlated with endometrial carcinoma pathogenesis. (PMID:32929617)
• Downregulation of LINC00958 inhibits proliferation, invasion and migration, and promotes apoptosis of colorectal cancer cells by targeting miR36195p. (PMID:32945474)
• LncRNA LINC00958 promotes tumor progression through miR-4306/CEMIP axis in osteosarcoma. (PMID:33928604)
• LncRNA LINC00958 Activates mTORC1/P70S6K Signalling Pathway to Promote Epithelial-Mesenchymal Transition Process in the Hepatocellular Carcinoma. (PMID:33979257)
• LINC00958 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of oesophageal squamous cell carcinoma cells. (PMID:34003875)
• The regulation of long non-coding RNA 00958 (LINC00958) for oral squamous cell carcinoma (OSCC) cells death through absent in melanoma 2 (AIM2) depending on microRNA-4306 and Sirtuin1 (SIRT1) in vitro. (PMID:34384029)
• m(6) A transferase KIAA1429-stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1. (PMID:34409730)
• Long non-coding RNA LINC00958 promotes colorectal cancer progression by enhancing the expression of LEM domain containing 1 via microRNA miR-3064-5p. (PMID:34672237)
• LINC00958/miR-3174/PHF6 axis is responsible for triggering proliferation, migration and invasion of endometrial cancer. (PMID:34859848)
• Highly Expressed LINC00958 Modulates the Growth and Epithelial-Mesenchymal Transition of Bladder Cancer Cells Through SAPK/JNK Signaling Pathway. (PMID:35766943)
• linc00958/miR-185-5p/RSF-1 modulates cisplatin resistance and angiogenesis through AKT1/GSK3beta/VEGFA pathway in cervical cancer. (PMID:36056431)
• The Long Noncoding RNA LINC00958 Is Induced in Psoriasis Epidermis and Modulates Epidermal Proliferation. (PMID:36641130)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.