LINC00965

Summary

LINC00965 (long intergenic non-protein coding RNA 965, HGNC:28022) is a long non-coding RNA gene on chromosome 8p23.1.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28022
Approved symbol	LINC00965
Name	long intergenic non-protein coding RNA 965
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Entrez	349196
RNAcentral	URS000075C1DB — lncRNA, 2874 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1156619397 (8:7261992 G>A), RS1158083650 (8:7263783 A>G), RS1158540514 (8:7263226 C>A), RS1159044484 (8:7263685 A>T), RS1159837465 (8:7263508 A>G), RS1160993068 (8:7264016 C>G), RS1161083610 (8:7263450 G>A), RS1161254789 (8:7263002 C>T), RS1161271727 (8:7263574 G>A), RS1163163132 (8:7261697 C>T), RS1164145479 (8:7263579 G>A,T), RS1166770513 (8:7263504 T>C), RS1168408556 (8:7263405 C>G), RS1168938059 (8:7262799 C>G), RS1169411112 (8:7263576 GA>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002927_15	Mercury levels	4.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, affects cotreatment, decreases expression	2
methylmercuric chloride	decreases expression	1
arsenite	affects binding, increases reaction	1
butyraldehyde	decreases expression	1
entinostat	decreases expression	1
Atrazine	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Silicon Dioxide	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Asbestos, Crocidolite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.