LINC00968

Summary

LINC00968 (long intergenic non-protein coding RNA 968, HGNC:48727) is a long non-coding RNA gene on chromosome 8q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48727
Approved symbol	LINC00968
Name	long intergenic non-protein coding RNA 968
Location	8q12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246430
Ensembl biotype	lncRNA
Entrez	100507632
RNAcentral	URS000075A7FC — lncRNA, 2531 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 44 lncRNA

ENST00000499425, ENST00000518943, ENST00000519144, ENST00000521483, ENST00000523166, ENST00000523664, ENST00000523724, ENST00000523786, ENST00000524338, ENST00000653444, ENST00000665904, ENST00000692050, ENST00000756198, ENST00000756199, ENST00000756200, ENST00000756201, ENST00000756202, ENST00000756203, ENST00000756204, ENST00000756205, ENST00000756206, ENST00000756207, ENST00000756208, ENST00000756209, ENST00000756210, ENST00000756211, ENST00000756212, ENST00000756213, ENST00000756214, ENST00000756215, ENST00000756216, ENST00000756217, ENST00000756218, ENST00000756219, ENST00000756220, ENST00000756221, ENST00000756222, ENST00000756223, ENST00000756224, ENST00000756225, ENST00000756226, ENST00000756227, ENST00000756791, ENST00000756792

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499425 — 3 exons

Exon	Start	End
ENSE00001970139	56520121	56520567
ENSE00004106046	56518318	56520020
ENSE00004106073	56559453	56559671

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 90.77.

FANTOM5 (CAGE): breadth broad, TPM avg 3.2932 / max 272.4941, expressed in 447 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
93177	2.6256	394
93179	0.2809	142
93180	0.1845	100
205190	0.1289	72
93178	0.0734	31

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.77	silver quality
right lung	UBERON:0002167	84.99	gold quality
colonic epithelium	UBERON:0000397	84.72	gold quality
monocyte	CL:0000576	81.49	gold quality
leukocyte	CL:0000738	80.99	gold quality
subcutaneous adipose tissue	UBERON:0002190	78.24	gold quality
adipose tissue	UBERON:0001013	76.68	gold quality
lung	UBERON:0002048	76.29	gold quality
upper lobe of left lung	UBERON:0008952	75.86	gold quality
upper lobe of lung	UBERON:0008948	75.00	gold quality
synovial joint	UBERON:0002217	73.31	gold quality
urethra	UBERON:0000057	73.18	gold quality
granulocyte	CL:0000094	71.85	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.61	gold quality
calcaneal tendon	UBERON:0003701	71.39	gold quality
adipose tissue of abdominal region	UBERON:0007808	70.35	gold quality
visceral pleura	UBERON:0002401	70.14	gold quality
stromal cell of endometrium	CL:0002255	70.06	gold quality
omental fat pad	UBERON:0010414	69.67	gold quality
peritoneum	UBERON:0002358	69.60	gold quality
skin of hip	UBERON:0001554	68.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.78	gold quality
tibial nerve	UBERON:0001323	68.69	gold quality
penis	UBERON:0000989	68.68	gold quality
layer of synovial tissue	UBERON:0007616	67.57	gold quality
gall bladder	UBERON:0002110	67.31	gold quality
apex of heart	UBERON:0002098	67.07	gold quality
bone marrow cell	CL:0002092	66.70	silver quality
thoracic mammary gland	UBERON:0005200	66.14	gold quality
mammary gland	UBERON:0001911	65.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• a prospective lncRNAmiRNA-mRNA regulatory network of LINC00968, three miRNAs (miR-9, miR-22 and miR-4536) and two genes (polo-like kinase 1 and exportin-1) was obtained following validation in the Cancer Genome Atlas database. These results may provide novel insights to support future research into lncRNA in lung cancer. (PMID:29039552)
• in our study, we found that PI3K/AKT/mTOR pathway was involved in osteosarcoma progression. Knockdown of LINC00968 inactivated PI3K/AKT/mTOR signaling pathway in vitro. Subsequently, in vivo tumor xenografts were established using 143-B cells to investigate whether LINC00968 can induce osteosarcoma development in vivo (PMID:29904919)
• LINC00968 accelerates the progression of epithelial ovarian cancer via mediating the cell cycle progression. (PMID:31210289)
• LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2. (PMID:33065511)
• LINC00968 can inhibit the progression of lung adenocarcinoma through the miR-21-5p/SMAD7 signal axis. (PMID:33147570)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.