LINC00973

Summary

LINC00973 (long intergenic non-protein coding RNA 973, HGNC:48868) is a long non-coding RNA gene on chromosome 3q12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48868
Approved symbol	LINC00973
Name	long intergenic non-protein coding RNA 973
Location	3q12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	L3EMP, CTD-2021J15.2
Ensembl gene	ENSG00000240476
Ensembl biotype	lncRNA
Entrez	105374003
RNAcentral	URS00026A1DE8 — lncRNA, 1275 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 47 — 47 lncRNA

ENST00000473756, ENST00000474798, ENST00000701980, ENST00000715231, ENST00000715232, ENST00000715233, ENST00000715234, ENST00000749131, ENST00000755838, ENST00000755839, ENST00000755840, ENST00000755841, ENST00000755842, ENST00000755843, ENST00000755844, ENST00000755845, ENST00000755846, ENST00000755847, ENST00000755848, ENST00000755849, ENST00000755850, ENST00000755851, ENST00000755852, ENST00000755853, ENST00000755854, ENST00000755855, ENST00000755856, ENST00000755857, ENST00000755858, ENST00000755859, ENST00000755860, ENST00000755861, ENST00000755862, ENST00000755863, ENST00000755864, ENST00000755865, ENST00000755866, ENST00000755867, ENST00000755868, ENST00000755869, ENST00000755870, ENST00000755871, ENST00000755872, ENST00000755873, ENST00000755874, ENST00000755875, ENST00000755876

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000473756 — 2 exons

Exon	Start	End
ENSE00004105305	98982464	98984483
ENSE00004105348	98981012	98981386

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 64.80.

FANTOM5 (CAGE): breadth broad, TPM avg 5.5784 / max 416.9309, expressed in 682 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
37566	1.8366	496
37559	0.9776	313
37560	0.7929	255
37564	0.6865	240
37562	0.6674	207
37565	0.2187	115
37561	0.2008	102
37563	0.1179	57
37567	0.0800	33

Top tissues by expression

172 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	64.80	gold quality
stromal cell of endometrium	CL:0002255	55.00	silver quality
islet of Langerhans	UBERON:0000006	51.02	gold quality
vermiform appendix	UBERON:0001154	50.06	gold quality
pancreas	UBERON:0001264	49.61	gold quality
prefrontal cortex	UBERON:0000451	49.16	gold quality
muscle of leg	UBERON:0001383	49.14	gold quality
monocyte	CL:0000576	48.46	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	48.11	gold quality
gall bladder	UBERON:0002110	48.09	gold quality
lymph node	UBERON:0000029	47.80	gold quality
lower lobe of lung	UBERON:0008949	47.43	silver quality
upper leg skin	UBERON:0004262	47.17	silver quality
skin of abdomen	UBERON:0001416	45.54	gold quality
caecum	UBERON:0001153	45.24	gold quality
cerebellar hemisphere	UBERON:0002245	44.88	silver quality
right lobe of liver	UBERON:0001114	44.50	silver quality
body of pancreas	UBERON:0001150	43.62	silver quality
left ovary	UBERON:0002119	43.44	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
heart left ventricle	UBERON:0002084	43.22	gold quality
lung	UBERON:0002048	43.12	silver quality
gastrocnemius	UBERON:0001388	43.09	silver quality
tonsil	UBERON:0002372	42.92	gold quality
heart	UBERON:0000948	42.75	silver quality
transverse colon	UBERON:0001157	42.59	silver quality
cardiac ventricle	UBERON:0002082	42.59	silver quality
secondary oocyte	CL:0000655	42.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	42.41	gold quality
adult mammalian kidney	UBERON:0000082	42.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00973 is involved in cancer immune suppression through positive regulation of Siglec-15 in clear-cell renal cell carcinoma. (PMID:32780490)
• LINC00973 Induces Proliferation Arrest of Drug-Treated Cancer Cells by Preventing p21 Degradation. (PMID:33171937)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.