LINC00974

Summary

LINC00974 (long intergenic non-protein coding RNA 974, HGNC:27105) is a long non-coding RNA gene on chromosome 17q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27105
Approved symbol	LINC00974
Name	long intergenic non-protein coding RNA 974
Location	17q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226629
Ensembl biotype	lncRNA
OMIM	620053
Entrez	147093
RNAcentral	URS0000432E9E — lncRNA, 2141 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000456403

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456403 — 3 exons

Exon	Start	End
ENSE00001598824	41551873	41552537
ENSE00001620371	41554280	41554495
ENSE00001787864	41549606	41550865

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 58.08.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	58.08	gold quality
ventricular zone	UBERON:0003053	57.24	silver quality
small intestine	UBERON:0002108	55.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	55.85	gold quality
pancreas	UBERON:0001264	53.84	silver quality
intestine	UBERON:0000160	53.14	gold quality
transverse colon	UBERON:0001157	52.54	gold quality
liver	UBERON:0002107	52.41	silver quality
muscle of leg	UBERON:0001383	52.35	silver quality
prefrontal cortex	UBERON:0000451	52.24	silver quality
colon	UBERON:0001155	51.81	gold quality
blood	UBERON:0000178	50.61	silver quality
rectum	UBERON:0001052	50.29	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	48.33	silver quality
muscle layer of sigmoid colon	UBERON:0035805	48.18	gold quality
left coronary artery	UBERON:0001626	46.83	gold quality
vermiform appendix	UBERON:0001154	44.64	silver quality
thoracic mammary gland	UBERON:0005200	44.16	gold quality
gastrocnemius	UBERON:0001388	44.02	silver quality
omental fat pad	UBERON:0010414	43.48	gold quality
adipose tissue	UBERON:0001013	43.28	gold quality
stomach	UBERON:0000945	42.76	silver quality
saliva-secreting gland	UBERON:0001044	42.75	silver quality
subcutaneous adipose tissue	UBERON:0002190	42.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	42.20	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	41.59	silver quality
lower esophagus muscularis layer	UBERON:0035833	41.50	gold quality
gall bladder	UBERON:0002110	41.48	silver quality
spleen	UBERON:0002106	41.40	silver quality
body of stomach	UBERON:0001161	41.03	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• MiR-642 regulates Linc00974 and KRT19 interaction determining tumor cell proliferation and metastasis in hepatocellular carcinoma. (PMID:25476897)
• findings suggested that arecoline-increased myofibroblast transdifferentiation was via LINC00974-mediated activation of TGF-beta signaling (PMID:30447113)
• arctigenin was shown to diminish the expression of LINC00974, which has been proven to activate TGF-b/Smad signaling for oral fibrogenesis. Taken together, we demonstrated that arctigenin may act as a suitable adjunct therapy for Oral submucous fibrosis . (PMID:30884781)
• In GC cells, LINC00974 overexpression led to upregulated, whereas LINC00974 siRNA silencing led to downregulated CDK6. Analysis of cell cycle progression and proliferation showed that LINC00974 and CDK6 overexpression promoted and siRNA silencing inhibited G1-S transition and cell proliferation. (PMID:31596614)
• LncRNA LINC00974 Downregulates miR-122 to Upregulate RhoA in Oral Squamous Cell Carcinoma. (PMID:31702382)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.