LINC00976

Summary

LINC00976 (long intergenic non-protein coding RNA 976, HGNC:50610) is a long non-coding RNA gene on chromosome 8q24.21.

At a glance

• GWAS associations: 2

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50610
Approved symbol	LINC00976
Name	long intergenic non-protein coding RNA 976
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Entrez	106144608
RNAcentral	URS0000ABD872 — lncRNA, 532 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The present study demonstrates that linc00976 enhances the proliferation and invasion ability of PC cells by upregulating OTUD7B expression, which was a target of miR-137. Ultimately, OTUD7B mediates EGFR and MAPK signaling pathway. (PMID:31747939)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000038563 (8:128967675 A>G), RS1000042070 (8:128965872 G>A), RS1000532497 (8:128956584 C>T), RS1000564284 (8:128955413 G>T), RS1000639760 (8:128967367 C>T), RS1000762341 (8:128961938 A>T), RS1000815090 (8:128961619 T>C), RS1000992209 (8:128967728 T>C), RS1001101930 (8:128962314 C>G), RS1001195743 (8:128960347 T>C), RS1001311504 (8:128954194 C>G), RS1001426080 (8:128966672 C>A,G), RS1001554604 (8:128962646 T>C), RS1001660955 (8:128953865 A>T), RS1001813684 (8:128960060 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST012304_5	Major depressive disorder	6.000000e-07
GCST90013406_44	Liver enzyme levels (alkaline phosphatase)	8.000000e-13

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.