LINC00977

Summary

LINC00977 (long intergenic non-protein coding RNA 977, HGNC:48902) is a long non-coding RNA gene on chromosome 8q24.21.

At a glance

• GWAS associations: 6

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48902
Approved symbol	LINC00977
Name	long intergenic non-protein coding RNA 977
Location	8q24.21
Locus type	RNA, long non-coding
Status	Approved
Entrez	728724
RNAcentral	URS000075EF7A — lncRNA, 1164 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000161994 (8:129238293 C>A,T), RS1000177399 (8:129242448 T>C), RS1000406641 (8:129232828 A>G), RS1000407220 (8:129227313 G>A,T), RS1000464293 (8:129218115 G>A,C), RS1000468281 (8:129226799 T>C), RS1000819878 (8:129233065 C>A), RS1000844888 (8:129232694 CA>C,CAA), RS1000903470 (8:129228428 A>G), RS1001066382 (8:129223130 T>A), RS1001298470 (8:129216865 T>C), RS1001544394 (8:129233523 G>A), RS1001681353 (8:129235636 C>A,T), RS1001736075 (8:129241533 T>C), RS1001749593 (8:129217133 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST002553_3	Pancreatic cancer	1.000000e-07
GCST004744_78	Lung adenocarcinoma	3.000000e-06
GCST005832_1	Acute lymphoblastic leukemia in childhood (B cell precursor)	4.000000e-09
GCST006979_372	Heel bone mineral density	4.000000e-12
GCST008644_14	Celiac disease and Rheumatoid arthritis	8.000000e-09
GCST008662_10	Lung function in never smokers (low FEV1 vs high FEV1)	4.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009270	heel bone mineral density
EFO:0004314	forced expiratory volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation	1
(+)-JQ1 compound	decreases expression	1
Propofol	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.