LINC00987

Summary

LINC00987 (long intergenic non-protein coding RNA 987, HGNC:48911) is a long non-coding RNA gene on chromosome 12p13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48911
Approved symbol	LINC00987
Name	long intergenic non-protein coding RNA 987
Location	12p13.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237248
Ensembl biotype	lncRNA
Entrez	100499405
RNAcentral	URS00025E35A1 — lncRNA, 2403 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000427111, ENST00000538219, ENST00000647751, ENST00000838855, ENST00000838856, ENST00000838857, ENST00000838858, ENST00000838859, ENST00000838860, ENST00000838861, ENST00000838862, ENST00000838863, ENST00000838864, ENST00000838865, ENST00000838866, ENST00000838867, ENST00000838868, ENST00000838869, ENST00000838870, ENST00000838871, ENST00000838872, ENST00000838873, ENST00000838874, ENST00000838875, ENST00000838876, ENST00000838877, ENST00000838878, ENST00000838879, ENST00000838880, ENST00000838881, ENST00000838882, ENST00000838883, ENST00000838884, ENST00000838885, ENST00000838886

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000427111 — 2 exons

Exon	Start	End
ENSE00004260538	9241118	9243056
ENSE00004260574	9240003	9240539

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 92.31.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8040 / max 16.2688, expressed in 477 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124047	0.7052	415
206579	0.0989	58

Top tissues by expression

135 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
quadriceps femoris	UBERON:0001377	92.31	gold quality
cerebellar vermis	UBERON:0004720	89.30	gold quality
corpus callosum	UBERON:0002336	88.01	gold quality
thymus	UBERON:0002370	82.26	silver quality
spinal cord	UBERON:0002240	81.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	81.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.86	gold quality
bone marrow cell	CL:0002092	78.21	gold quality
substantia nigra	UBERON:0002038	77.60	gold quality
gall bladder	UBERON:0002110	75.50	gold quality
spleen	UBERON:0002106	74.97	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.45	gold quality
Ammon’s horn	UBERON:0001954	74.08	gold quality
nucleus accumbens	UBERON:0001882	73.84	gold quality
temporal lobe	UBERON:0001871	73.00	gold quality
amygdala	UBERON:0001876	72.93	gold quality
right lobe of liver	UBERON:0001114	72.75	gold quality
right adrenal gland cortex	UBERON:0035827	72.70	gold quality
caudate nucleus	UBERON:0001873	72.65	gold quality
liver	UBERON:0002107	72.54	gold quality
right adrenal gland	UBERON:0001233	72.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.38	gold quality
granulocyte	CL:0000094	72.23	gold quality
putamen	UBERON:0001874	71.94	gold quality
hypothalamus	UBERON:0001898	71.86	gold quality
right lung	UBERON:0002167	71.81	gold quality
upper lobe of left lung	UBERON:0008952	71.44	gold quality
left adrenal gland cortex	UBERON:0035825	71.23	gold quality
placenta	UBERON:0001987	71.03	gold quality
lung	UBERON:0002048	70.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC00987 Ameliorates COPD by Regulating LPS-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Autophagy Through Let-7b-5p/SIRT1 Axis. (PMID:33311978)
• Hypomethylation-associated LINC00987 downregulation induced lung adenocarcinoma progression by inhibiting the phosphorylation-mediated degradation of SND1. (PMID:38607240)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.