LINC00994

Summary

LINC00994 (long intergenic non-protein coding RNA 994, HGNC:48949) is a long non-coding RNA gene on chromosome 3p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48949
Approved symbol	LINC00994
Name	long intergenic non-protein coding RNA 994
Location	3p14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000189196
Ensembl biotype	lncRNA
Entrez	100287879
RNAcentral	URS00003A8C02 — lncRNA, 2129 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000485805

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000485805 — 4 exons

Exon	Start	End
ENSE00001498226	64078361	64079235
ENSE00001498227	64079835	64080007
ENSE00001871475	64083091	64083684
ENSE00002071040	64086877	64087363

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 52.45.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
fundus of stomach	UBERON:0001160	52.45	gold quality
prefrontal cortex	UBERON:0000451	52.00	silver quality
endometrium	UBERON:0001295	51.97	gold quality
myometrium	UBERON:0001296	47.75	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	47.12	gold quality
vermiform appendix	UBERON:0001154	46.10	silver quality
islet of Langerhans	UBERON:0000006	45.42	silver quality
gall bladder	UBERON:0002110	45.24	silver quality
endocervix	UBERON:0000458	45.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	45.01	silver quality
tibial artery	UBERON:0007610	44.63	silver quality
smooth muscle tissue	UBERON:0001135	44.56	gold quality
adrenal gland	UBERON:0002369	44.45	gold quality
adult mammalian kidney	UBERON:0000082	44.44	gold quality
lymph node	UBERON:0000029	44.38	silver quality
heart left ventricle	UBERON:0002084	44.20	silver quality
placenta	UBERON:0001987	44.16	silver quality
right atrium auricular region	UBERON:0006631	43.92	silver quality
cerebral cortex	UBERON:0000956	43.76	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	43.57	silver quality
body of uterus	UBERON:0009853	43.27	gold quality
right coronary artery	UBERON:0001625	43.25	gold quality
heart	UBERON:0000948	43.23	silver quality
hypothalamus	UBERON:0001898	42.63	gold quality
ectocervix	UBERON:0012249	42.56	gold quality
omental fat pad	UBERON:0010414	42.42	silver quality
body of pancreas	UBERON:0001150	42.34	silver quality
adipose tissue	UBERON:0001013	42.10	silver quality
body of stomach	UBERON:0001161	42.01	silver quality
esophagus	UBERON:0001043	41.87	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.62

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Findings indicated that decreased expression of LINC00994 in T2DM patients was associated with T2DM susceptibility in an Iranian population. (PMID:30043104)
• that LINC00994 and RUNX2 are upregulated in pancreatic cancers as compared to non-cancer tissues, while miR-765-3p is downregulated. Silencing of LINC00994 inhibits the growth, migration and invasion, promotes a G1 cell cycle arrest and apoptosis in pancreatic cancer cells in vitro. (PMID:30739523)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.