LINC00997

Summary

LINC00997 (long intergenic non-protein coding RNA 997, HGNC:48952) is a long non-coding RNA gene on chromosome 7p14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48952
Approved symbol	LINC00997
Name	long intergenic non-protein coding RNA 997
Location	7p14.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000281332
Ensembl biotype	lncRNA
Entrez	401321
RNAcentral	URS000075E1E0 — lncRNA, 4639 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000628855

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000628855 — 1 exons

Exon	Start	End
ENSE00003771639	32760279	32762924

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 75.65.

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	75.65	gold quality
apex of heart	UBERON:0002098	75.56	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.39	silver quality
cardiac ventricle	UBERON:0002082	74.82	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.70	gold quality
cerebellar hemisphere	UBERON:0002245	74.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.28	gold quality
cerebellar cortex	UBERON:0002129	74.27	gold quality
muscle layer of sigmoid colon	UBERON:0035805	73.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	73.54	gold quality
lower esophagus	UBERON:0013473	73.49	gold quality
popliteal artery	UBERON:0002250	73.48	gold quality
tibial artery	UBERON:0007610	73.45	gold quality
right atrium auricular region	UBERON:0006631	73.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.00	gold quality
body of pancreas	UBERON:0001150	72.54	gold quality
aorta	UBERON:0000947	72.51	gold quality
cardiac atrium	UBERON:0002081	72.41	gold quality
heart	UBERON:0000948	72.23	gold quality
cerebellum	UBERON:0002037	72.03	gold quality
right coronary artery	UBERON:0001625	71.70	gold quality
descending thoracic aorta	UBERON:0002345	71.68	gold quality
thoracic aorta	UBERON:0001515	71.66	gold quality
ventricular zone	UBERON:0003053	71.61	gold quality
ascending aorta	UBERON:0001496	71.58	gold quality
spinal cord	UBERON:0002240	71.21	gold quality
body of uterus	UBERON:0009853	70.94	gold quality
right uterine tube	UBERON:0001302	70.61	gold quality
body of stomach	UBERON:0001161	70.58	gold quality
pancreas	UBERON:0001264	70.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.02

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The LINC00997-STAT3-S100A11 axis may promote the development of kidney renal clear cell carcinoma. (PMID:31442606)
• Long non-coding RNA LINC00997 silencing inhibits the progression and metastasis of colorectal cancer by sponging miR-512-3p. (PMID:33570445)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.