LINC01013

Summary

LINC01013 (long intergenic non-protein coding RNA 1013, HGNC:48987) is a long non-coding RNA gene on chromosome 6q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48987
Approved symbol	LINC01013
Name	long intergenic non-protein coding RNA 1013
Location	6q23.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	AERRIE, LINC01013ORF
Ensembl gene	ENSG00000228495
Ensembl biotype	lncRNA
OMIM	621228
Entrez	100507254
RNAcentral	URS00026A1DDF — lncRNA, 955 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 135 — 135 lncRNA

ENST00000419695, ENST00000421310, ENST00000422700, ENST00000430428, ENST00000435287, ENST00000436112, ENST00000440246, ENST00000443303, ENST00000447481, ENST00000454596, ENST00000458028, ENST00000622916, ENST00000653266, ENST00000654779, ENST00000655558, ENST00000655844, ENST00000656169, ENST00000657473, ENST00000658258, ENST00000658894, ENST00000660058, ENST00000660563, ENST00000660939, ENST00000661099, ENST00000661280, ENST00000662166, ENST00000662967, ENST00000663205, ENST00000664107, ENST00000664113, ENST00000665843, ENST00000666171, ENST00000666560, ENST00000667512, ENST00000667763, ENST00000668744, ENST00000669240, ENST00000669461, ENST00000669653, ENST00000670122, ENST00000706294, ENST00000706295, ENST00000706296, ENST00000706305, ENST00000706306, ENST00000706307, ENST00000706308, ENST00000706309, ENST00000706310, ENST00000706311, ENST00000706312, ENST00000706313, ENST00000706314, ENST00000706315, ENST00000706316, ENST00000706317, ENST00000706318, ENST00000706319, ENST00000706322, ENST00000706323, ENST00000706324, ENST00000706325, ENST00000706326, ENST00000706327, ENST00000706328, ENST00000706329, ENST00000706330, ENST00000706331, ENST00000706332, ENST00000706333, ENST00000706334, ENST00000706335, ENST00000706336, ENST00000706337, ENST00000706338, ENST00000706339, ENST00000706340, ENST00000706341, ENST00000706342, ENST00000706343, ENST00000706344, ENST00000706345, ENST00000706346, ENST00000706347, ENST00000706348, ENST00000706349, ENST00000706350, ENST00000706351, ENST00000706352, ENST00000706353, ENST00000706354, ENST00000706355, ENST00000706356, ENST00000706357, ENST00000706358, ENST00000706359, ENST00000773261, ENST00000773262, ENST00000773263, ENST00000773264, ENST00000773265, ENST00000773266, ENST00000773267, ENST00000773268, ENST00000773269, ENST00000773270, ENST00000773271, ENST00000773272, ENST00000773273, ENST00000773274, ENST00000773275, ENST00000773276, ENST00000773277, ENST00000773278, ENST00000773279, ENST00000773280, ENST00000773281, ENST00000773282, ENST00000773283, ENST00000773284, ENST00000773285, ENST00000773286, ENST00000773287, ENST00000773288, ENST00000773289, ENST00000773290, ENST00000773291, ENST00000773292, ENST00000773293, ENST00000773294, ENST00000773295, ENST00000773296, ENST00000773297, ENST00000773298, ENST00000773299

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419695 — 2 exons

Exon	Start	End
ENSE00001614945	131903648	131904234
ENSE00003995464	131907406	131907502

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 80.98.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.2307 / max 200.7533, expressed in 182 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
69811	0.4458	90
69815	0.2337	51
69816	0.2031	70
69812	0.1815	70
69813	0.1334	76
69814	0.0332	12

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	80.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.77	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.70	gold quality
right testis	UBERON:0004534	73.52	gold quality
calcaneal tendon	UBERON:0003701	72.82	gold quality
left testis	UBERON:0004533	72.70	gold quality
mucosa of transverse colon	UBERON:0004991	70.83	gold quality
testis	UBERON:0000473	70.74	gold quality
vena cava	UBERON:0004087	70.11	gold quality
bone marrow cell	CL:0002092	69.09	silver quality
sperm	CL:0000019	69.08	silver quality
tibialis anterior	UBERON:0001385	68.22	silver quality
kidney epithelium	UBERON:0004819	66.46	gold quality
lymph node	UBERON:0000029	66.32	gold quality
tendon of biceps brachii	UBERON:0008188	66.19	gold quality
sural nerve	UBERON:0015488	65.71	gold quality
bone marrow	UBERON:0002371	65.34	gold quality
ventricular zone	UBERON:0003053	65.11	gold quality
tendon	UBERON:0000043	64.17	gold quality
vermiform appendix	UBERON:0001154	63.59	gold quality
ileal mucosa	UBERON:0000331	63.35	silver quality
tonsil	UBERON:0002372	63.07	gold quality
upper arm skin	UBERON:0004263	63.07	gold quality
stromal cell of endometrium	CL:0002255	62.88	gold quality
ganglionic eminence	UBERON:0004023	62.71	gold quality
pancreatic ductal cell	CL:0002079	62.31	silver quality
buccal mucosa cell	CL:0002336	62.16	silver quality
granulocyte	CL:0000094	62.10	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.46	gold quality
rectum	UBERON:0001052	61.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Collectively, these findings support a potential role for LINC01013 in cancer cell invasion through the snail-fibronectin activation cascade. (PMID:28331184)
• Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features. (PMID:33847733)
• Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve. (PMID:35041643)
• LINC01013 Is a Determinant of Fibroblast Activation and Encodes a Novel Fibroblast-Activating Micropeptide. (PMID:35759180)
• Negative Regulation of LINC01013 by METTL3 and YTHDF2 Enhances the Osteogenic Differentiation of Senescent Pre-Osteoblast Cells Induced by Hydrogen Peroxide. (PMID:38548669)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.