LINC01014

Summary

LINC01014 (long intergenic non-protein coding RNA 1014, HGNC:41353) is a long non-coding RNA gene on chromosome 3q26.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41353
Approved symbol	LINC01014
Name	long intergenic non-protein coding RNA 1014
Location	3q26.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223941
Ensembl biotype	lncRNA
Entrez	100874330
RNAcentral	URS000007FFF1 — lncRNA, 548 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000436432, ENST00000441018, ENST00000455307

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436432 — 3 exons

Exon	Start	End
ENSE00001624610	178419234	178419375
ENSE00001703362	178456614	178456774
ENSE00001769302	178457068	178457309

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 82.62.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5393 / max 300.2554, expressed in 64 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
39905	0.4576	60
39904	0.0817	23

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	82.62	gold quality
right uterine tube	UBERON:0001302	79.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.19	silver quality
fallopian tube	UBERON:0003889	70.50	gold quality
pancreas	UBERON:0001264	67.29	gold quality
endocervix	UBERON:0000458	65.78	gold quality
adult mammalian kidney	UBERON:0000082	65.52	gold quality
kidney	UBERON:0002113	65.21	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.08	gold quality
adenohypophysis	UBERON:0002196	61.16	gold quality
cortex of kidney	UBERON:0001225	59.48	gold quality
pituitary gland	UBERON:0000007	59.20	gold quality
gall bladder	UBERON:0002110	58.65	gold quality
corpus callosum	UBERON:0002336	58.06	gold quality
endometrium	UBERON:0001295	57.80	gold quality
superior frontal gyrus	UBERON:0002661	57.37	gold quality
prefrontal cortex	UBERON:0000451	57.23	gold quality
body of pancreas	UBERON:0001150	57.07	gold quality
blood	UBERON:0000178	56.49	gold quality
stromal cell of endometrium	CL:0002255	54.53	silver quality
liver	UBERON:0002107	54.30	gold quality
caudate nucleus	UBERON:0001873	53.86	gold quality
Brodmann (1909) area 9	UBERON:0013540	53.69	gold quality
left adrenal gland cortex	UBERON:0035825	53.29	gold quality
gastrocnemius	UBERON:0001388	52.09	gold quality
multicellular organism	UBERON:0000468	51.74	gold quality
brain	UBERON:0000955	51.41	gold quality
right lobe of liver	UBERON:0001114	51.32	gold quality
lung	UBERON:0002048	50.91	gold quality
rectum	UBERON:0001052	50.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.85

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Linc01014 regulates gefitinib resistance in oesophagus cancer via EGFR-PI3K-AKT-mTOR signalling pathway. (PMID:31785047)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.