LINC01060

Summary

LINC01060 (long intergenic non-protein coding RNA 1060, HGNC:49081) is a long non-coding RNA gene on chromosome 4q35.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49081
Approved symbol	LINC01060
Name	long intergenic non-protein coding RNA 1060
Location	4q35.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249378
Ensembl biotype	lncRNA
Entrez	401164
RNAcentral	URS000075D257 — lncRNA, 483 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 75 — 75 lncRNA

ENST00000503458, ENST00000503580, ENST00000510005, ENST00000510832, ENST00000512839, ENST00000513313, ENST00000655286, ENST00000656246, ENST00000657654, ENST00000657685, ENST00000659977, ENST00000662888, ENST00000663631, ENST00000664177, ENST00000664234, ENST00000666634, ENST00000666759, ENST00000667003, ENST00000667271, ENST00000667802, ENST00000667883, ENST00000685943, ENST00000692519, ENST00000701950, ENST00000806915, ENST00000806916, ENST00000806917, ENST00000806918, ENST00000806919, ENST00000806920, ENST00000806921, ENST00000806922, ENST00000806923, ENST00000806924, ENST00000806925, ENST00000806926, ENST00000806927, ENST00000806928, ENST00000806929, ENST00000806930, ENST00000806931, ENST00000806932, ENST00000806933, ENST00000806934, ENST00000806935, ENST00000806936, ENST00000806937, ENST00000806938, ENST00000806939, ENST00000806940, ENST00000806941, ENST00000806942, ENST00000806943, ENST00000806944, ENST00000806945, ENST00000806946, ENST00000806947, ENST00000806948, ENST00000806949, ENST00000806950, ENST00000806951, ENST00000806952, ENST00000806953, ENST00000806954, ENST00000806955, ENST00000806956, ENST00000806957, ENST00000806958, ENST00000806959, ENST00000806960, ENST00000806961, ENST00000806962, ENST00000806963, ENST00000806964, ENST00000806965

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503458 — 4 exons

Exon	Start	End
ENSE00002031910	188485779	188485865
ENSE00002033132	188456664	188456762
ENSE00004200490	188601768	188602508
ENSE00004200499	188455532	188455674

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 81.85.

FANTOM5 (CAGE): breadth broad, TPM avg 5.1838 / max 637.0833, expressed in 405 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
50936	1.4025	108
50940	0.8953	118
50941	0.7662	74
203460	0.6177	41
50939	0.5229	126
50945	0.3307	156
50943	0.2990	62
50938	0.1449	65
50937	0.1043	56
50942	0.1003	53

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.85	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.95	gold quality
adult mammalian kidney	UBERON:0000082	75.21	gold quality
islet of Langerhans	UBERON:0000006	72.87	gold quality
sural nerve	UBERON:0015488	70.26	gold quality
kidney	UBERON:0002113	70.20	gold quality
right lobe of liver	UBERON:0001114	68.09	gold quality
thoracic mammary gland	UBERON:0005200	66.53	gold quality
liver	UBERON:0002107	65.30	gold quality
cortex of kidney	UBERON:0001225	65.07	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.02	gold quality
right testis	UBERON:0004534	64.06	gold quality
testis	UBERON:0000473	63.95	gold quality
left testis	UBERON:0004533	62.86	gold quality
gall bladder	UBERON:0002110	60.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	59.32	gold quality
cortical plate	UBERON:0005343	58.76	silver quality
metanephros cortex	UBERON:0010533	58.19	gold quality
monocyte	CL:0000576	57.93	gold quality
ganglionic eminence	UBERON:0004023	57.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	57.28	gold quality
adipose tissue	UBERON:0001013	57.27	gold quality
bone marrow	UBERON:0002371	57.11	gold quality
right coronary artery	UBERON:0001625	56.99	gold quality
descending thoracic aorta	UBERON:0002345	56.13	gold quality
primary visual cortex	UBERON:0002436	56.07	gold quality
muscle tissue	UBERON:0002385	55.89	gold quality
calcaneal tendon	UBERON:0003701	55.79	gold quality
substantia nigra	UBERON:0002038	55.55	gold quality
right atrium auricular region	UBERON:0006631	55.41	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	60.24
E-ANND-3	no	1.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Results show that Linc01060 expression is downregulated in pancreatic tumors and associates with poor prognosis. Further data demonstrate that Linc01060 plays a key role in suppressing pancreatic cancer progression by regulating vinculin expression. (PMID:29913236)
• Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1alpha Axis. (PMID:33158815)
• LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling. (PMID:37211864)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.