LINC01081

Summary

LINC01081 (long intergenic non-protein coding RNA 1081, HGNC:49124) is a long non-coding RNA gene on chromosome 16q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49124
Approved symbol	LINC01081
Name	long intergenic non-protein coding RNA 1081
Location	16q24.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00024764
Ensembl gene	ENSG00000268754
Ensembl biotype	lncRNA
OMIM	614977
Entrez	101154687
RNAcentral	URS000075C4F2 — lncRNA, 736 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000597373, ENST00000602425, ENST00000667546, ENST00000806422, ENST00000806423, ENST00000806424, ENST00000806425, ENST00000806426, ENST00000806427

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000597373 — 6 exons

Exon	Start	End
ENSE00002977390	86225847	86225962
ENSE00003055606	86225580	86225667
ENSE00003070244	86275703	86275822
ENSE00003147923	86226640	86226777
ENSE00003200328	86269004	86269083
ENSE00003817235	86301172	86301303

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 90.10.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1358 / max 12.0872, expressed in 58 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158434	0.1358	58

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.10	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.64	gold quality
urinary bladder	UBERON:0001255	69.73	gold quality
rectum	UBERON:0001052	68.33	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.30	gold quality
right testis	UBERON:0004534	66.09	gold quality
left testis	UBERON:0004533	65.59	gold quality
mucosa of transverse colon	UBERON:0004991	64.97	gold quality
colon	UBERON:0001155	64.89	gold quality
testis	UBERON:0000473	64.88	gold quality
gall bladder	UBERON:0002110	64.44	gold quality
intestine	UBERON:0000160	64.07	gold quality
fundus of stomach	UBERON:0001160	64.03	gold quality
colonic epithelium	UBERON:0000397	63.93	silver quality
transverse colon	UBERON:0001157	63.57	gold quality
mucosa of stomach	UBERON:0001199	62.84	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.57	gold quality
body of stomach	UBERON:0001161	62.24	gold quality
right lung	UBERON:0002167	62.18	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.07	gold quality
small intestine	UBERON:0002108	61.97	gold quality
stomach	UBERON:0000945	61.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.83	gold quality
lower esophagus	UBERON:0013473	61.79	gold quality
vermiform appendix	UBERON:0001154	61.23	gold quality
muscle tissue	UBERON:0002385	60.18	gold quality
cortical plate	UBERON:0005343	59.14	gold quality
prostate gland	UBERON:0002367	58.30	gold quality
placenta	UBERON:0001987	57.20	gold quality
stromal cell of endometrium	CL:0002255	56.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.58

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• decrease in LINC01081 expression can contribute to development of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). (PMID:24842713)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.