LINC01094

Summary

LINC01094 (long intergenic non-protein coding RNA 1094, HGNC:49219) is a long non-coding RNA gene on chromosome 4q21.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49219
Approved symbol	LINC01094
Name	long intergenic non-protein coding RNA 1094
Location	4q21.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	CTEPHA1, lincRNA-ANXA3
Ensembl gene	ENSG00000251442
Ensembl biotype	lncRNA
Entrez	100505702
RNAcentral	URS000075BC36 — lncRNA, 4300 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 43 — 43 lncRNA

ENST00000503259, ENST00000503539, ENST00000504675, ENST00000507802, ENST00000512322, ENST00000514130, ENST00000652918, ENST00000653916, ENST00000654343, ENST00000654792, ENST00000656991, ENST00000661741, ENST00000663250, ENST00000666953, ENST00000667455, ENST00000668669, ENST00000670146, ENST00000671622, ENST00000687467, ENST00000701241, ENST00000701906, ENST00000778503, ENST00000778504, ENST00000778505, ENST00000778506, ENST00000778507, ENST00000778508, ENST00000778509, ENST00000778510, ENST00000778511, ENST00000778512, ENST00000778513, ENST00000778514, ENST00000778515, ENST00000778516, ENST00000778517, ENST00000778518, ENST00000778519, ENST00000778520, ENST00000778521, ENST00000778522, ENST00000778523, ENST00000778524

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503259 — 3 exons

Exon	Start	End
ENSE00002022128	78645870	78646263
ENSE00002055518	78649601	78649709
ENSE00003883818	78662918	78664974

Expression profiles

Bgee: expression breadth ubiquitous, 189 present calls, max score 86.87.

FANTOM5 (CAGE): breadth broad, TPM avg 3.8923 / max 482.8741, expressed in 451 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
48460	2.3272	226
48456	0.6784	278
48459	0.6569	216
48457	0.1563	85
48458	0.0735	36

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spinal cord	UBERON:0002240	86.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.46	gold quality
substantia nigra	UBERON:0002038	83.09	gold quality
midbrain	UBERON:0001891	81.55	gold quality
hypothalamus	UBERON:0001898	81.49	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.46	gold quality
corpus callosum	UBERON:0002336	77.01	gold quality
monocyte	CL:0000576	75.60	gold quality
leukocyte	CL:0000738	75.24	gold quality
substantia nigra pars compacta	UBERON:0001965	74.94	gold quality
medulla oblongata	UBERON:0001896	74.85	gold quality
substantia nigra pars reticulata	UBERON:0001966	74.28	gold quality
amygdala	UBERON:0001876	74.27	gold quality
superior vestibular nucleus	UBERON:0007227	74.22	gold quality
amniotic fluid	UBERON:0000173	72.82	gold quality
medial globus pallidus	UBERON:0002477	72.49	gold quality
subthalamic nucleus	UBERON:0001906	72.16	gold quality
vermiform appendix	UBERON:0001154	71.95	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.93	silver quality
Ammon’s horn	UBERON:0001954	71.40	gold quality
ventral tegmental area	UBERON:0002691	71.34	gold quality
anterior cingulate cortex	UBERON:0009835	71.05	gold quality
stromal cell of endometrium	CL:0002255	70.99	gold quality
caudate nucleus	UBERON:0001873	70.19	gold quality
globus pallidus	UBERON:0001875	69.89	gold quality
nucleus accumbens	UBERON:0001882	69.51	gold quality
lateral globus pallidus	UBERON:0002476	69.27	gold quality
temporal lobe	UBERON:0001871	68.93	gold quality
right frontal lobe	UBERON:0002810	67.82	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.73	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Upregulation of LINC01094 was confirmed in Clear cell renal cell carcinoma (ccRCC) cell lines, and functional experiments delineated that LINC01094 knockdown led to inhibition on ccRCC cell growth and metastasis. Moreover, LINC01094 was activated by FOXM1 at the transcriptional level. (PMID:31767633)
• Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis. (PMID:34657558)
• LncRNA LINC01094 contributes to glioma progression by modulating miR-224-5p/CHSY1 axis. (PMID:34716872)
• LINC01094 Predicts Poor Prognosis in Patients With Gastric Cancer and is Correlated With EMT and Macrophage Infiltration. (PMID:35254147)
• Upregulated long intergenic non-protein coding RNA 1094 (LINC01094) is linked to poor prognosis and alteration of cell function in colorectal cancer. (PMID:35287563)
• LINC01094/SPI1/CCL7 Axis Promotes Macrophage Accumulation in Lung Adenocarcinoma and Tumor Cell Dissemination. (PMID:36118415)
• LINC01094 accelerates the metastasis of hepatocellular carcinoma via the miR-26b-3p/MDM4 axis. (PMID:37605571)
• LINC01094 promotes human nasal epithelial cell epithelial-to-mesenchymal transition and pyroptosis via upregulating HMGB1. (PMID:37864411)
• Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis. (PMID:38758016)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.