LINC01116

Summary

LINC01116 (long intergenic non-protein coding RNA 1116, HGNC:49259) is a long non-coding RNA gene on chromosome 2q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49259
Approved symbol	LINC01116
Name	long intergenic non-protein coding RNA 1116
Location	2q31.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TALNEC2
Ensembl gene	ENSG00000163364
Ensembl biotype	lncRNA
Entrez	375295
RNAcentral	URS00026A23ED — lncRNA, 1085 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000295549, ENST00000339037, ENST00000658669, ENST00000695928, ENST00000698425, ENST00000703418, ENST00000814979, ENST00000814980

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000295549 — 3 exons

Exon	Start	End
ENSE00001421028	176633033	176633125
ENSE00003965499	176629572	176630432
ENSE00003965501	176637462	176637931

Expression profiles

Bgee: expression breadth ubiquitous, 175 present calls, max score 97.12.

FANTOM5 (CAGE): breadth broad, TPM avg 3.4222 / max 132.9588, expressed in 762 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31963	2.4809	611
31965	0.4531	287
31966	0.2825	119
31964	0.2056	91

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	97.12	gold quality
germinal epithelium of ovary	UBERON:0001304	93.50	gold quality
seminal vesicle	UBERON:0000998	88.80	gold quality
kidney epithelium	UBERON:0004819	88.50	silver quality
caput epididymis	UBERON:0004358	88.41	gold quality
calcaneal tendon	UBERON:0003701	84.08	gold quality
cauda epididymis	UBERON:0004360	83.73	gold quality
metanephros	UBERON:0000081	83.72	gold quality
metanephros cortex	UBERON:0010533	83.12	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.30	gold quality
right adrenal gland cortex	UBERON:0035827	82.10	gold quality
smooth muscle tissue	UBERON:0001135	81.95	gold quality
ovary	UBERON:0000992	81.92	gold quality
tendon	UBERON:0000043	81.91	gold quality
tendon of biceps brachii	UBERON:0008188	81.32	gold quality
layer of synovial tissue	UBERON:0007616	80.93	gold quality
left adrenal gland cortex	UBERON:0035825	80.88	gold quality
adult mammalian kidney	UBERON:0000082	80.80	gold quality
left adrenal gland	UBERON:0001234	80.51	gold quality
kidney	UBERON:0002113	80.38	gold quality
right ovary	UBERON:0002118	80.31	gold quality
adrenal cortex	UBERON:0001235	80.06	gold quality
left ovary	UBERON:0002119	79.76	gold quality
right adrenal gland	UBERON:0001233	79.63	gold quality
adrenal gland	UBERON:0002369	79.46	gold quality
body of uterus	UBERON:0009853	79.33	gold quality
cortex of kidney	UBERON:0001225	78.50	gold quality
spleen	UBERON:0002106	78.29	gold quality
upper arm skin	UBERON:0004263	77.00	gold quality
colonic epithelium	UBERON:0000397	76.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• The expression of TALNEC2 is associated with the increased tumorigenic potential of GSCs and their resistance to radiation. We conclude that TALNEC2 is an attractive therapeutic target for the treatment of GBM. (PMID:28423669)
• RNA immunoprecipitation indicated that LINC01116 and VEGFA were present in the miR-31-5p-RISC complex, and biotinylated miR-31-5p pull-down assay suggested that there was a competitive relationship between LINC01116 and VEGFA to bind with miR-31-5p (PMID:31144303)
• Knockdown of LINC01116 inhibits cell migration and invasion in head and neck squamous cell carcinoma through epithelial-mesenchymal transition pathway. (PMID:31452270)
• LINC01116 promotes proliferation, invasion and migration of osteosarcoma cells by silencing p53 and EZH2. (PMID:31486480)
• LINC01116 accelerates nasopharyngeal carcinoma progression based on its enhancement on MYC transcription activity. (PMID:31703161)
• LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1beta in glioma cell. (PMID:32358484)
• The relationship between the lncRNA model and prognosis as well as clinical characteristics of patients with HCC was analyzed. Finally, a predictive nomogram in the the cancer genome atlas cohort was established and verified internallyBased on the RNA sequencing survival analysis, a 9- lncRNAs prognosis model, including TMCC1-AS1, AC008892.1, AL031985.3, L34079.2, U95743.1, KDM4A-AS1, SACS-AS1, AC005534.1, LINC01116. (PMID:32481346)
• Long non-coding RNA LINC01116 accelerates the progression of keloid formation by regulating miR-203/SMAD5 axis. (PMID:32883538)
• LINC01116 promotes proliferation and migration of endometrial stromal cells by targeting FOXP1 via sponging miR-9-5p in endometriosis. (PMID:33372387)
• LINC01116 facilitates colorectal cancer cell proliferation and angiogenesis through targeting EZH2-regulated TPM1. (PMID:33499872)
• LncRNA LINC01116 sponges miR-93-5p to promote cell invasion and migration in small cell lung cancer. (PMID:33535997)
• LINC01116 promotes the proliferation and invasion of glioma by regulating the microRNA7445pMDM2p53 axis. (PMID:33760190)
• Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway. (PMID:34061456)
• LINC01116 boosts the progression of pituitary adenoma via regulating miR-744-5p/HOXB8 pathway. (PMID:34098015)
• LINC01116 Regulates the Proliferation and Apoptosis of Nucleus Pulposus Cells through miR-9-5p-mediated ZIC5 and the Wnt Pathway and Affects the Progression of Intervertebral Disc Degeneration. (PMID:35927800)
• The mechanism of lncRNA TALNEC2 regulating miR-19a-3p/JNK to alleviate cerebral ischemia injury in rats with acute cerebral infarction. (PMID:36227683)
• LINC01116 modulates EMT process via binding with AGO1 mRNA in oesophageal squamous cell carcinoma. (PMID:36990227)
• LINC01116 affects patient survival differently and is dissimilarly expressed in ER+ and ER- breast cancer samples. (PMID:37321964)
• Comprehensive analysis of candidate signatures of long non-coding RNA LINC01116 and related protein-coding genes in patients with hepatocellular carcinoma. (PMID:37340445)
• Linc01116 Silencing Inhibits the Proliferation and Invasion, Promotes Apoptosis of Chordoma Cells via Regulating the Expression of Mir-9-5p/PKG1. (PMID:37489776)
• Hypoxia-induced factor-1alpha promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia. (PMID:37983895)
• LINC01116-dependent upregulation of RNA polymerase I transcription drives oncogenic phenotypes in lung adenocarcinoma. (PMID:39369230)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.