LINC01118

Summary

LINC01118 (long intergenic non-protein coding RNA 1118, HGNC:49261) is a long non-coding RNA gene on chromosome 2p21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49261
Approved symbol	LINC01118
Name	long intergenic non-protein coding RNA 1118
Location	2p21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000222005
Ensembl biotype	lncRNA
Entrez	388948
RNAcentral	URS000075B300 — lncRNA, 1058 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 123 — 123 lncRNA

ENST00000409518, ENST00000409912, ENST00000422294, ENST00000468141, ENST00000479311, ENST00000490950, ENST00000495449, ENST00000650611, ENST00000653090, ENST00000686485, ENST00000692576, ENST00000759077, ENST00000759078, ENST00000759079, ENST00000759080, ENST00000759081, ENST00000759082, ENST00000759083, ENST00000759084, ENST00000759085, ENST00000759086, ENST00000759087, ENST00000759088, ENST00000759089, ENST00000759090, ENST00000759091, ENST00000759092, ENST00000759093, ENST00000759094, ENST00000759095, ENST00000759096, ENST00000759097, ENST00000759098, ENST00000759099, ENST00000759100, ENST00000759101, ENST00000759102, ENST00000759103, ENST00000759104, ENST00000759105, ENST00000759106, ENST00000759107, ENST00000759108, ENST00000759109, ENST00000759110, ENST00000759111, ENST00000759112, ENST00000759113, ENST00000759114, ENST00000759115, ENST00000759116, ENST00000759117, ENST00000759118, ENST00000759119, ENST00000759120, ENST00000759121, ENST00000759122, ENST00000759123, ENST00000759124, ENST00000759125, ENST00000759126, ENST00000759127, ENST00000759128, ENST00000759129, ENST00000759130, ENST00000759131, ENST00000759132, ENST00000759133, ENST00000759134, ENST00000759135, ENST00000759136, ENST00000759137, ENST00000759138, ENST00000759139, ENST00000759140, ENST00000759141, ENST00000759142, ENST00000759143, ENST00000759144, ENST00000759145, ENST00000759146, ENST00000759147, ENST00000759148, ENST00000759149, ENST00000759150, ENST00000759151, ENST00000759152, ENST00000759153, ENST00000759154, ENST00000759155, ENST00000759156, ENST00000759157, ENST00000759158, ENST00000759159, ENST00000759160, ENST00000759161, ENST00000759162, ENST00000759163, ENST00000759164, ENST00000759165, ENST00000759465, ENST00000759466, ENST00000759467, ENST00000759468, ENST00000759469, ENST00000759470, ENST00000759471, ENST00000759472, ENST00000759473, ENST00000759474, ENST00000759475, ENST00000759476, ENST00000759477, ENST00000759478, ENST00000759479, ENST00000759480, ENST00000759481, ENST00000759482, ENST00000759483, ENST00000759484, ENST00000759485, ENST00000759486, ENST00000759487

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000409518 — 3 exons

Exon	Start	End
ENSE00001576705	46818180	46818231
ENSE00001583548	46822101	46822657
ENSE00001584826	46816688	46816912

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 97.42.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0057 / max 5.0526, expressed in 3 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
20104	1.5891	779
20111	0.0057	3

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	97.42	gold quality
secondary oocyte	CL:0000655	94.84	gold quality
upper arm skin	UBERON:0004263	85.56	gold quality
left ventricle myocardium	UBERON:0006566	82.44	gold quality
cardiac muscle of right atrium	UBERON:0003379	82.29	gold quality
myocardium	UBERON:0002349	81.84	gold quality
parotid gland	UBERON:0001831	79.12	gold quality
nasal cavity epithelium	UBERON:0005384	78.66	gold quality
heart right ventricle	UBERON:0002080	77.70	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	76.96	gold quality
biceps brachii	UBERON:0001507	75.34	gold quality
kidney epithelium	UBERON:0004819	74.96	gold quality
vastus lateralis	UBERON:0001379	74.30	gold quality
quadriceps femoris	UBERON:0001377	73.97	gold quality
placenta	UBERON:0001987	72.98	gold quality
cerebellar vermis	UBERON:0004720	72.95	gold quality
muscle tissue	UBERON:0002385	70.24	silver quality
middle temporal gyrus	UBERON:0002771	69.83	gold quality
skeletal muscle tissue	UBERON:0001134	69.38	gold quality
bone marrow	UBERON:0002371	68.79	gold quality
sperm	CL:0000019	68.36	gold quality
cartilage tissue	UBERON:0002418	68.08	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	68.03	gold quality
endothelial cell	CL:0000115	67.68	gold quality
decidua	UBERON:0002450	67.61	gold quality
epithelial cell of pancreas	CL:0000083	67.56	gold quality
Brodmann (1909) area 23	UBERON:0013554	67.06	gold quality
entorhinal cortex	UBERON:0002728	67.01	gold quality
mucosa of paranasal sinus	UBERON:0005030	66.42	gold quality
pancreatic ductal cell	CL:0002079	66.37	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01118 was highly expressed in EOC tissues and chemoresistant cells. Biological function experiments showed LINC01118 could facilitate paclitaxel resistance and promote migration and invasion while inhibiting apoptosis of EOC cells. (PMID:30521500)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.