LINC01121

Summary

LINC01121 (long intergenic non-protein coding RNA 1121, HGNC:49266) is a long non-coding RNA gene on chromosome 2p21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49266
Approved symbol	LINC01121
Name	long intergenic non-protein coding RNA 1121
Location	2p21
Locus type	RNA, long non-coding
Status	Approved
Aliases	UNQ6975
Ensembl gene	ENSG00000205054
Ensembl biotype	lncRNA
Entrez	400952
RNAcentral	URS000075D120 — lncRNA, 1114 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 17 lncRNA, 1 retained_intron

ENST00000378479, ENST00000413669, ENST00000427020, ENST00000430650, ENST00000454673, ENST00000658738, ENST00000745753, ENST00000745754, ENST00000745755, ENST00000811459, ENST00000811460, ENST00000811461, ENST00000811462, ENST00000811463, ENST00000811464, ENST00000811465, ENST00000811466, ENST00000811467

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000378479 — 6 exons

Exon	Start	End
ENSE00001477659	45174344	45174587
ENSE00001477660	45175115	45175213
ENSE00001477662	45189121	45189249
ENSE00001477664	45190883	45191084
ENSE00001477667	45192140	45192285
ENSE00001477668	45254667	45254941

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 77.98.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1981 / max 33.4042, expressed in 66 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
28169	0.1188	50
28168	0.0792	27

Top tissues by expression

226 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.98	gold quality
calcaneal tendon	UBERON:0003701	69.96	gold quality
tendon	UBERON:0000043	68.03	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.97	gold quality
buccal mucosa cell	CL:0002336	67.34	gold quality
tendon of biceps brachii	UBERON:0008188	65.69	silver quality
parotid gland	UBERON:0001831	59.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.81	gold quality
myocardium	UBERON:0002349	58.61	gold quality
secondary oocyte	CL:0000655	58.38	gold quality
mucosa of sigmoid colon	UBERON:0004993	58.26	gold quality
nasal cavity epithelium	UBERON:0005384	58.21	gold quality
bone marrow	UBERON:0002371	58.04	gold quality
colonic mucosa	UBERON:0000317	57.80	gold quality
ectocervix	UBERON:0012249	57.73	gold quality
peritoneum	UBERON:0002358	57.58	gold quality
omental fat pad	UBERON:0010414	57.58	gold quality
islet of Langerhans	UBERON:0000006	57.48	gold quality
gingival epithelium	UBERON:0001949	57.33	gold quality
vena cava	UBERON:0004087	57.19	gold quality
amniotic fluid	UBERON:0000173	56.97	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	56.72	gold quality
adipose tissue of abdominal region	UBERON:0007808	56.66	gold quality
muscle of leg	UBERON:0001383	56.55	gold quality
cerebellar vermis	UBERON:0004720	56.52	gold quality
apex of heart	UBERON:0002098	56.31	gold quality
biceps brachii	UBERON:0001507	56.25	gold quality
gingiva	UBERON:0001828	55.90	gold quality
mucosa of paranasal sinus	UBERON:0005030	55.89	gold quality
pituitary gland	UBERON:0000007	55.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01121 induced intervertebral disc degeneration via modulating miR-150-5p/MMP16 axis. (PMID:32436632)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.