LINC01123

Summary

LINC01123 (long intergenic non-protein coding RNA 1123, HGNC:49269) is a long non-coding RNA gene on chromosome 2q13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49269
Approved symbol	LINC01123
Name	long intergenic non-protein coding RNA 1123
Location	2q13
Locus type	RNA, long non-coding
Status	Approved
Aliases	YG-6
Ensembl gene	ENSG00000204588
Ensembl biotype	lncRNA
Entrez	440894
RNAcentral	URS000075DA1D — lncRNA, 2519 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000336905, ENST00000419296, ENST00000767830, ENST00000767831, ENST00000767832, ENST00000767833, ENST00000767834

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000336905 — 2 exons

Exon	Start	End
ENSE00001256270	109988272	109988802
ENSE00001628801	109994401	109996140

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 95.14.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1215 / max 5.9754, expressed in 69 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21929	0.1215	69

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primary visual cortex	UBERON:0002436	95.14	gold quality
superior frontal gyrus	UBERON:0002661	94.66	gold quality
prefrontal cortex	UBERON:0000451	90.96	gold quality
frontal cortex	UBERON:0001870	89.91	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.61	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.36	gold quality
mucosa of transverse colon	UBERON:0004991	88.40	gold quality
right frontal lobe	UBERON:0002810	88.26	gold quality
cerebral cortex	UBERON:0000956	87.44	gold quality
nucleus accumbens	UBERON:0001882	85.76	gold quality
body of pancreas	UBERON:0001150	85.61	gold quality
anterior cingulate cortex	UBERON:0009835	85.46	gold quality
putamen	UBERON:0001874	82.73	gold quality
metanephros cortex	UBERON:0010533	81.94	gold quality
caudate nucleus	UBERON:0001873	81.71	gold quality
pancreas	UBERON:0001264	80.52	gold quality
brain	UBERON:0000955	80.30	gold quality
hypothalamus	UBERON:0001898	79.14	gold quality
Ammon’s horn	UBERON:0001954	78.95	gold quality
duodenum	UBERON:0002114	78.93	gold quality
cortex of kidney	UBERON:0001225	78.91	gold quality
right lobe of thyroid gland	UBERON:0001119	78.84	gold quality
left lobe of thyroid gland	UBERON:0001120	78.62	gold quality
ascending aorta	UBERON:0001496	78.15	gold quality
small intestine	UBERON:0002108	78.08	gold quality
temporal lobe	UBERON:0001871	78.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.00	gold quality
thoracic aorta	UBERON:0001515	77.93	gold quality
amygdala	UBERON:0001876	77.82	gold quality
thyroid gland	UBERON:0002046	77.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Functional assays showed that LINC01123 promoted NSCLC cell proliferation and aerobic glycolysis. Mechanistic investigations revealed that LINC01123 was a direct transcriptional target of c-Myc. LINC01123 increased c-Myc mRNA expression by sponging miR-199a-5p. (PMID:31488218)
• LINC01123 facilitates proliferation, invasion and chemoresistance of colon cancer cells. (PMID:32700743)
• ZEB1-activated LINC01123 accelerates the malignancy in lung adenocarcinoma through NOTCH signaling pathway. (PMID:33191397)
• LINC01123 enhances osteosarcoma cell growth by activating the Hedgehog pathway via the miR-516b-5p/Gli1 axis. (PMID:33837611)
• LINC01123 promotes cell proliferation and migration via regulating miR-1277-5p/KLF5 axis in ox-LDL-induced vascular smooth muscle cells. (PMID:34403009)
• LINC01123 is associated with prognosis of oral squamous cell carcinoma and involved in tumor progression by sponging miR-34a-5p. (PMID:34511356)
• LINC01123 potentially correlates with radioresistance in glioma through the miR-151a/CENPB axis. (PMID:34519373)
• LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma. (PMID:35115487)
• Long non-coding RNA LINC01123 promotes cell proliferation, migration and invasion via interacting with SRSF7 in colorectal cancer. (PMID:35325644)
• LINC01123 acts as an oncogenic driver in lung adenocarcinoma by regulating the miR-4766-5p/PYCR1 axis. (PMID:36994814)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.