LINC01126

Summary

LINC01126 (long intergenic non-protein coding RNA 1126, HGNC:49275) is a long non-coding RNA gene on chromosome 2p21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49275
Approved symbol	LINC01126
Name	long intergenic non-protein coding RNA 1126
Location	2p21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000279873
Ensembl biotype	lncRNA
Entrez	100129726
RNAcentral	URS000075E8A9 — lncRNA, 1698 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 31 lncRNA

ENST00000423354, ENST00000623515, ENST00000660392, ENST00000717220, ENST00000717221, ENST00000829698, ENST00000829699, ENST00000829700, ENST00000829701, ENST00000829702, ENST00000829703, ENST00000829704, ENST00000829705, ENST00000829706, ENST00000829707, ENST00000829708, ENST00000829709, ENST00000829710, ENST00000829711, ENST00000829712, ENST00000829713, ENST00000829714, ENST00000829715, ENST00000829716, ENST00000829717, ENST00000829718, ENST00000829719, ENST00000829720, ENST00000829721, ENST00000829722, ENST00000829723

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000423354 — 4 exons

Exon	Start	End
ENSE00001597956	43232764	43232901
ENSE00001699849	43229544	43229616
ENSE00001777683	43233179	43233452
ENSE00004031938	43219806	43220057

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 71.39.

FANTOM5 (CAGE): breadth broad, TPM avg 2.6112 / max 39.4510, expressed in 848 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19977	1.5737	635
19978	1.0375	382

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	71.39	gold quality
bone marrow cell	CL:0002092	69.63	silver quality
granulocyte	CL:0000094	68.88	gold quality
body of uterus	UBERON:0009853	66.03	gold quality
right lobe of thyroid gland	UBERON:0001119	64.95	gold quality
left lobe of thyroid gland	UBERON:0001120	64.55	gold quality
colonic epithelium	UBERON:0000397	64.50	silver quality
vermiform appendix	UBERON:0001154	64.17	gold quality
cortical plate	UBERON:0005343	63.89	gold quality
thyroid gland	UBERON:0002046	63.81	gold quality
buccal mucosa cell	CL:0002336	63.33	gold quality
left ovary	UBERON:0002119	63.16	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.00	gold quality
lymph node	UBERON:0000029	62.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.95	gold quality
lower esophagus	UBERON:0013473	61.88	gold quality
popliteal artery	UBERON:0002250	61.82	gold quality
tibial artery	UBERON:0007610	61.80	gold quality
left uterine tube	UBERON:0001303	61.71	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.68	gold quality
monocyte	CL:0000576	61.67	gold quality
ganglionic eminence	UBERON:0004023	61.62	gold quality
spleen	UBERON:0002106	61.39	gold quality
small intestine	UBERON:0002108	61.26	gold quality
right ovary	UBERON:0002118	60.99	gold quality
ventricular zone	UBERON:0003053	60.79	gold quality
aorta	UBERON:0000947	60.65	gold quality
descending thoracic aorta	UBERON:0002345	60.64	gold quality
apex of heart	UBERON:0002098	60.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA 01126 promotes periodontitis pathogenesis of human periodontal ligament cells via miR-518a-5p/HIF-1alpha/MAPK pathway. (PMID:33231338)
• Androgen-repressed lncRNA LINC01126 drives castration-resistant prostate cancer by regulating the switch between O-GlcNAcylation and phosphorylation of androgen receptor. (PMID:38214432)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.