LINC01128

Summary

LINC01128 (long intergenic non-protein coding RNA 1128, HGNC:49377) is a long non-coding RNA gene on chromosome 1p36.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49377
Approved symbol	LINC01128
Name	long intergenic non-protein coding RNA 1128
Location	1p36.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-206L10.11
Ensembl gene	ENSG00000228794
Ensembl biotype	lncRNA
Entrez	643837
RNAcentral	URS000075B941 — lncRNA, 6776 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 95 — 94 lncRNA, 1 retained_intron

ENST00000415295, ENST00000416570, ENST00000425657, ENST00000441765, ENST00000445118, ENST00000448975, ENST00000449005, ENST00000608189, ENST00000609009, ENST00000609139, ENST00000610067, ENST00000622921, ENST00000623070, ENST00000623808, ENST00000624927, ENST00000657175, ENST00000657837, ENST00000658846, ENST00000659124, ENST00000660797, ENST00000661237, ENST00000661463, ENST00000666741, ENST00000667414, ENST00000668541, ENST00000669922, ENST00000670780, ENST00000670824, ENST00000671208, ENST00000685334, ENST00000685566, ENST00000685764, ENST00000685879, ENST00000686238, ENST00000688008, ENST00000688309, ENST00000688420, ENST00000691234, ENST00000691316, ENST00000692194, ENST00000701598, ENST00000701768, ENST00000702098, ENST00000702273, ENST00000702557, ENST00000702847, ENST00000744865, ENST00000744866, ENST00000744867, ENST00000744868, ENST00000744869, ENST00000744870, ENST00000744871, ENST00000744872, ENST00000744873, ENST00000744874, ENST00000744875, ENST00000744876, ENST00000744877, ENST00000744878, ENST00000744879, ENST00000744880, ENST00000744881, ENST00000744882, ENST00000744883, ENST00000744884, ENST00000744885, ENST00000744886, ENST00000744887, ENST00000744888, ENST00000744889, ENST00000744890, ENST00000744891, ENST00000744892, ENST00000744893, ENST00000744894, ENST00000744895, ENST00000744896, ENST00000744897, ENST00000744898, ENST00000744899, ENST00000744900, ENST00000744901, ENST00000744902, ENST00000744903, ENST00000744904, ENST00000744905, ENST00000744906, ENST00000745642, ENST00000745643, ENST00000745644, ENST00000745645, ENST00000745646, ENST00000745647, ENST00000745648

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000415295 — 2 exons

Exon	Start	End
ENSE00001614719	841200	842020
ENSE00001802996	831605	831677

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 98.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.3489 / max 59.7410, expressed in 1315 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
16	2.0640	1188
15	0.1533	48
17	0.1236	41
18	0.0080	2

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	98.93	gold quality
oocyte	CL:0000023	98.71	gold quality
left ventricle myocardium	UBERON:0006566	96.35	gold quality
sperm	CL:0000019	95.52	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.40	gold quality
apex of heart	UBERON:0002098	94.69	gold quality
heart left ventricle	UBERON:0002084	93.68	gold quality
cardiac ventricle	UBERON:0002082	93.48	gold quality
cardiac atrium	UBERON:0002081	93.01	gold quality
pituitary gland	UBERON:0000007	92.95	gold quality
adenohypophysis	UBERON:0002196	92.88	gold quality
right atrium auricular region	UBERON:0006631	92.88	gold quality
tendon of biceps brachii	UBERON:0008188	92.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.54	gold quality
gastrocnemius	UBERON:0001388	92.43	gold quality
heart	UBERON:0000948	92.20	gold quality
muscle of leg	UBERON:0001383	91.98	gold quality
myocardium	UBERON:0002349	90.98	gold quality
cortical plate	UBERON:0005343	90.75	gold quality
right lobe of liver	UBERON:0001114	90.62	gold quality
islet of Langerhans	UBERON:0000006	90.59	gold quality
cerebellar vermis	UBERON:0004720	90.06	gold quality
cerebellum	UBERON:0002037	89.95	gold quality
cerebellar cortex	UBERON:0002129	89.90	gold quality
cerebellar hemisphere	UBERON:0002245	89.90	gold quality
left testis	UBERON:0004533	89.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	89.69	gold quality
postcentral gyrus	UBERON:0002581	89.65	gold quality
medial globus pallidus	UBERON:0002477	89.31	gold quality
right testis	UBERON:0004534	89.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Long intergenic non-protein coding RNA 1128 (LINC01128) displays high expression in cervical cancer (CC) tissues. LINC01128 shortage reduces the expression of stratifin (SFN) at mRNA and protein levels. LINC01128 enhances cell proliferation, migration and invasion as well as inhibits cell apoptosis by binding with miR-383-5p and upregulating SFN. (PMID:31779593)
• LINC01128 regulates the development of osteosarcoma by sponging miR-299-3p to mediate MMP2 expression and activating Wnt/beta-catenin signalling pathway. (PMID:33108067)
• LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells. (PMID:33881945)
• Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p. (PMID:36382487)
• ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in beta2GPI/anti-beta2GPI-treated monocytes. (PMID:38224186)
• Upregulated lncRNA LINC01128 in colorectal cancer accelerates cell growth and predicts malignant prognosis through sponging miR-363-3p. (PMID:38796816)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.