LINC01138

Summary

LINC01138 (long intergenic non-protein coding RNA 1138, HGNC:49454) is a long non-coding RNA gene on chromosome 1q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49454
Approved symbol	LINC01138
Name	long intergenic non-protein coding RNA 1138
Location	1q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ39739, MP60
Ensembl gene	ENSG00000274020
Ensembl biotype	lncRNA
Entrez	388685
RNAcentral	URS000075E356 — lncRNA, 2075 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 269 — 268 lncRNA, 1 retained_intron

ENST00000434245, ENST00000440862, ENST00000445201, ENST00000613452, ENST00000614292, ENST00000622328, ENST00000638958, ENST00000639159, ENST00000639181, ENST00000640832, ENST00000652758, ENST00000653634, ENST00000658866, ENST00000658938, ENST00000715667, ENST00000715668, ENST00000760719, ENST00000760720, ENST00000760721, ENST00000760722, ENST00000760723, ENST00000760724, ENST00000760725, ENST00000760726, ENST00000760727, ENST00000760728, ENST00000760729, ENST00000760730, ENST00000760731, ENST00000760732, ENST00000760733, ENST00000760734, ENST00000760735, ENST00000760736, ENST00000760737, ENST00000760738, ENST00000760739, ENST00000760740, ENST00000760741, ENST00000760742, ENST00000760743, ENST00000760744, ENST00000760745, ENST00000760746, ENST00000760747, ENST00000760748, ENST00000760749, ENST00000760750, ENST00000760751, ENST00000760752, ENST00000760753, ENST00000760754, ENST00000760755, ENST00000760756, ENST00000760757, ENST00000760758, ENST00000760759, ENST00000760760, ENST00000760761, ENST00000760762, ENST00000760763, ENST00000760764, ENST00000760765, ENST00000760766, ENST00000760767, ENST00000760768, ENST00000760769, ENST00000760770, ENST00000760771, ENST00000760772, ENST00000760773, ENST00000760774, ENST00000760775, ENST00000760776, ENST00000760777, ENST00000760778, ENST00000760779, ENST00000760780, ENST00000760781, ENST00000760782, ENST00000760783, ENST00000760784, ENST00000760785, ENST00000760786, ENST00000760787, ENST00000760788, ENST00000760789, ENST00000760790, ENST00000760791, ENST00000760792, ENST00000760793, ENST00000760794, ENST00000760795, ENST00000760796, ENST00000760797, ENST00000760798, ENST00000760799, ENST00000760800, ENST00000760801, ENST00000760802, ENST00000760803, ENST00000760804, ENST00000760805, ENST00000760806, ENST00000760807, ENST00000760808, ENST00000760809, ENST00000760810, ENST00000760811, ENST00000760812, ENST00000760813, ENST00000760814, ENST00000760815, ENST00000760816, ENST00000760817, ENST00000760818, ENST00000760819, ENST00000760820, ENST00000760821, ENST00000760822, ENST00000760823, ENST00000760824, ENST00000760825, ENST00000760826, ENST00000760827, ENST00000760828, ENST00000760829, ENST00000760830, ENST00000760831, ENST00000760832, ENST00000760833, ENST00000760834, ENST00000760835, ENST00000760836, ENST00000760837, ENST00000760838, ENST00000760839, ENST00000760840, ENST00000760841, ENST00000760842, ENST00000760843, ENST00000760844, ENST00000760845, ENST00000760846, ENST00000760847, ENST00000760848, ENST00000760849, ENST00000760850, ENST00000760851, ENST00000760852, ENST00000760853, ENST00000760854, ENST00000760855, ENST00000760856, ENST00000760857, ENST00000760858, ENST00000760859, ENST00000760860, ENST00000760861, ENST00000760862, ENST00000760863, ENST00000760864, ENST00000760865, ENST00000760866, ENST00000760867, ENST00000760868, ENST00000760869, ENST00000760870, ENST00000760871, ENST00000760872, ENST00000760873, ENST00000760874, ENST00000760875, ENST00000760876, ENST00000760877, ENST00000760878, ENST00000760879, ENST00000760880, ENST00000760881, ENST00000760882, ENST00000760883, ENST00000760884, ENST00000760885, ENST00000760886, ENST00000760887, ENST00000760888, ENST00000760889, ENST00000760890, ENST00000760891, ENST00000760892, ENST00000760893, ENST00000760894, ENST00000760895, ENST00000760896, ENST00000760897, ENST00000760898, ENST00000760899, ENST00000760900, ENST00000760901, ENST00000760902, ENST00000760903, ENST00000760904, ENST00000760905, ENST00000760906, ENST00000760907, ENST00000760908, ENST00000760909, ENST00000760910, ENST00000760911, ENST00000760912, ENST00000760913, ENST00000760914, ENST00000760915, ENST00000760916, ENST00000760917, ENST00000760918, ENST00000760919, ENST00000760920, ENST00000760921, ENST00000760922, ENST00000760923, ENST00000760924, ENST00000760925, ENST00000760926, ENST00000760927, ENST00000760928, ENST00000760929, ENST00000760930, ENST00000760931, ENST00000760932, ENST00000760933, ENST00000760934, ENST00000760935, ENST00000760936, ENST00000760937, ENST00000760938, ENST00000760939, ENST00000760940, ENST00000760941, ENST00000760942, ENST00000760943, ENST00000760944, ENST00000760945, ENST00000760946, ENST00000760947, ENST00000760948, ENST00000760949, ENST00000760950, ENST00000760951, ENST00000760952, ENST00000760953, ENST00000760954, ENST00000760955, ENST00000760956, ENST00000760957, ENST00000760958, ENST00000760959, ENST00000760960, ENST00000760961, ENST00000760962, ENST00000760963, ENST00000760964, ENST00000760965, ENST00000760966, ENST00000760967, ENST00000760968, ENST00000760969, ENST00000760970, ENST00000760971

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434245 — 6 exons

Exon	Start	End
ENSE00001630131	148295750	148295913
ENSE00001632311	148296273	148296499
ENSE00001632373	148296124	148296182
ENSE00001696836	148297129	148297271
ENSE00001704973	148292914	148293048
ENSE00001734617	148290890	148291301

Expression profiles

Bgee: expression breadth ubiquitous, 226 present calls, max score 93.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0349 / max 4.4851, expressed in 17 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201694	0.0349	17

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	93.77	gold quality
granulocyte	CL:0000094	90.03	gold quality
oviduct epithelium	UBERON:0004804	89.61	gold quality
blood	UBERON:0000178	88.98	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.14	gold quality
spleen	UBERON:0002106	86.47	gold quality
cerebellar hemisphere	UBERON:0002245	86.47	gold quality
cerebellar cortex	UBERON:0002129	86.39	gold quality
anterior cingulate cortex	UBERON:0009835	85.53	gold quality
leukocyte	CL:0000738	85.33	gold quality
monocyte	CL:0000576	85.29	gold quality
adenohypophysis	UBERON:0002196	85.21	gold quality
cerebellum	UBERON:0002037	85.18	gold quality
right frontal lobe	UBERON:0002810	85.03	gold quality
endothelial cell	CL:0000115	84.84	gold quality
sperm	CL:0000019	84.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.37	gold quality
endometrium epithelium	UBERON:0004811	84.09	silver quality
body of pancreas	UBERON:0001150	84.07	gold quality
pituitary gland	UBERON:0000007	84.04	gold quality
amygdala	UBERON:0001876	83.80	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.77	gold quality
bone marrow cell	CL:0002092	83.43	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.35	gold quality
hypothalamus	UBERON:0001898	83.22	gold quality
nucleus accumbens	UBERON:0001882	83.11	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.89	gold quality
minor salivary gland	UBERON:0001830	82.74	gold quality
prostate gland	UBERON:0002367	82.69	gold quality
endocervix	UBERON:0000458	82.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• LINC01138 interacts with PRMT5 to increase arginine methylation and protein stability of SREBP1, promoting lipid desaturation and cell proliferation in Clear cell renal cell carcinoma. (PMID:30446222)
• Silencing long noncoding RNA LINC01138 inhibits aerobic glycolysis to reduce glioma cell proliferation by regulating the microRNA375/SP1 axis. (PMID:34643249)
• Metabolism-related lncRNAs signature to predict the prognosis of colon adenocarcinoma. (PMID:36366731)
• Knockdown of LINC01138 protects human chondrocytes against IL-1beta-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis. (PMID:36705420)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.