LINC01139

Summary

LINC01139 (long intergenic non-protein coding RNA 1139, HGNC:27924) is a long non-coding RNA gene on chromosome 1q43.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27924
Approved symbol	LINC01139
Name	long intergenic non-protein coding RNA 1139
Location	1q43
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINK-A, TCONS_00000027
Ensembl gene	ENSG00000215808
Ensembl biotype	lncRNA
Entrez	339535
RNAcentral	URS000075A909 — lncRNA, 1540 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000400946, ENST00000648188, ENST00000648241, ENST00000649127, ENST00000649385, ENST00000649681, ENST00000657655

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000400946 — 2 exons

Exon	Start	End
ENSE00004147255	238480362	238481681
ENSE00004147256	238485785	238486053

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 82.97.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5478 / max 63.0498, expressed in 453 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
18244	0.7962	327
18243	0.7516	319

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	82.97	silver quality
tibial artery	UBERON:0007610	82.69	gold quality
popliteal artery	UBERON:0002250	82.66	gold quality
corpus epididymis	UBERON:0004359	80.40	gold quality
oviduct epithelium	UBERON:0004804	79.74	gold quality
body of uterus	UBERON:0009853	79.69	gold quality
metanephros cortex	UBERON:0010533	79.66	gold quality
caput epididymis	UBERON:0004358	79.24	gold quality
fallopian tube	UBERON:0003889	79.02	gold quality
right uterine tube	UBERON:0001302	78.44	gold quality
adult mammalian kidney	UBERON:0000082	76.73	gold quality
stromal cell of endometrium	CL:0002255	76.05	gold quality
endocervix	UBERON:0000458	75.99	gold quality
seminal vesicle	UBERON:0000998	75.69	gold quality
epithelium of nasopharynx	UBERON:0001951	75.13	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.76	gold quality
kidney	UBERON:0002113	74.58	gold quality
tibial nerve	UBERON:0001323	74.21	gold quality
cortex of kidney	UBERON:0001225	73.54	gold quality
smooth muscle tissue	UBERON:0001135	73.14	gold quality
myometrium	UBERON:0001296	72.60	gold quality
aorta	UBERON:0000947	72.55	gold quality
calcaneal tendon	UBERON:0003701	71.59	gold quality
uterus	UBERON:0000995	71.35	gold quality
metanephros	UBERON:0000081	70.71	gold quality
left uterine tube	UBERON:0001303	70.66	gold quality
germinal epithelium of ovary	UBERON:0001304	69.67	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	68.94	silver quality
endometrium	UBERON:0001295	68.60	gold quality
parietal pleura	UBERON:0002400	68.15	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Both LINK-A expression and LINK-A-dependent signalling pathway activation correlate with triple-negative breast cancer, promoting breast cancer glycolysis reprogramming and tumorigenesis. (PMID:26751287)
• LINK-A-dependent AKT hyperactivation leads to tumorigenesis and resistance to AKT inhibitors. (PMID:28218907)
• LDH-A was involved in the LINK-A-mediated proliferation. (PMID:28714007)
• LINK-A lncRNA may promote migration and invasion of ovarian carcinoma cells by activating TGF-beta pathway. (PMID:30061183)
• Long noncoding RNA LINC01139 promotes the progression of hepatocellular carcinoma by upregulating MYBL2 via competitively binding to miR-30 family. (PMID:32115147)
• High expression of long non-coding RNA Linc-A associates with poor survival in patients with colorectal cancer. (PMID:32918124)
• The Biological Role of the Long Non-coding RNA LINK-A in Ovarian Carcinoma. (PMID:33288561)
• The role of long intergenic non-coding RNA for kinase activation (LINK-A) as an oncogene in non-small cell lung carcinoma. (PMID:33602983)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.