LINC01140

Summary

LINC01140 (long intergenic non-protein coding RNA 1140, HGNC:27922) is a long non-coding RNA gene on chromosome 1p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27922
Approved symbol	LINC01140
Name	long intergenic non-protein coding RNA 1140
Location	1p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ41676
Ensembl gene	ENSG00000267272
Ensembl biotype	lncRNA
Entrez	339524
RNAcentral	URS000075CD48 — lncRNA, 3429 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000461990, ENST00000467438, ENST00000469312, ENST00000471417, ENST00000476432, ENST00000484933, ENST00000490006, ENST00000587165, ENST00000589455, ENST00000590653, ENST00000619924

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000461990 — 2 exons

Exon	Start	End
ENSE00001817369	87133614	87136669
ENSE00001822814	87129870	87129994

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 86.42.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5437 / max 115.8156, expressed in 275 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
3891	0.7972	210
3892	0.1996	93
3890	0.1987	77
3893	0.1415	60
3894	0.0950	42
3887	0.0521	24
3888	0.0327	16
3889	0.0270	13

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right atrium auricular region	UBERON:0006631	86.42	gold quality
pancreatic ductal cell	CL:0002079	84.74	gold quality
omental fat pad	UBERON:0010414	84.71	gold quality
peritoneum	UBERON:0002358	84.59	gold quality
cardiac atrium	UBERON:0002081	83.93	gold quality
subcutaneous adipose tissue	UBERON:0002190	83.28	gold quality
adipose tissue of abdominal region	UBERON:0007808	83.04	gold quality
calcaneal tendon	UBERON:0003701	82.26	gold quality
tibial nerve	UBERON:0001323	82.21	gold quality
apex of heart	UBERON:0002098	82.20	gold quality
left ovary	UBERON:0002119	80.65	gold quality
smooth muscle tissue	UBERON:0001135	80.50	gold quality
left coronary artery	UBERON:0001626	80.14	gold quality
tibialis anterior	UBERON:0001385	79.75	silver quality
anterior cingulate cortex	UBERON:0009835	79.62	gold quality
gall bladder	UBERON:0002110	79.49	gold quality
right lobe of thyroid gland	UBERON:0001119	79.42	gold quality
right ovary	UBERON:0002118	79.30	gold quality
left lobe of thyroid gland	UBERON:0001120	78.84	gold quality
coronary artery	UBERON:0001621	77.99	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.97	gold quality
heart	UBERON:0000948	77.85	gold quality
adipose tissue	UBERON:0001013	77.59	gold quality
thyroid gland	UBERON:0002046	77.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.96	gold quality
upper lobe of left lung	UBERON:0008952	76.91	gold quality
heart left ventricle	UBERON:0002084	76.72	gold quality
right coronary artery	UBERON:0001625	76.53	gold quality
right lung	UBERON:0002167	76.50	gold quality
cardiac ventricle	UBERON:0002082	75.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• The long noncoding RNA LINC01140/miR-140-5p/FGF9 axis modulates bladder cancer cell aggressiveness and macrophage M2 polarization. (PMID:33234721)
• High Levels of LINC01140 Expression Predict a Good Prognosis and Improve Radiotherapy in Sarcoma Patients. (PMID:34587432)
• LINC01140 inhibits nonsmall cell lung cancer progression and cisplatin resistance through the miR-4742-5p/TACC1 axis. (PMID:35307914)
• LINC01140 Regulates Radiosensitivity of Nasopharyngeal Carcinoma Cells Through the ceRNA Network. (PMID:35988287)
• LINC01140 Targeting miR-452-5p/RGS2 Pathway to Attenuate Breast Cancer Tumorigenesis. (PMID:36299824)
• Exosome-Mediated lncRNA LINC01140 Attenuates Breast Cancer Progression by Regulating the Wnt/beta-Catenin Pathway. (PMID:37602451)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.