LINC01159

Summary

LINC01159 (long intergenic non-protein coding RNA 1159, HGNC:49514) is a long non-coding RNA gene on chromosome 2q12.1.

Predicted to act upstream of or within cerebellar cortex structural organization; homeostasis of number of cells within a tissue; and regulation of gene expression. Predicted to be located in cytoplasm and nucleus.

Source: NCBI Gene 102682016 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49514
Approved symbol	LINC01159
Name	long intergenic non-protein coding RNA 1159
Location	2q12.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-Brn1b
Ensembl gene	ENSG00000229743
Ensembl biotype	lncRNA
OMIM	618208
Entrez	102682016
RNAcentral	URS000075CFA1 — lncRNA, 3246 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 41 — 41 lncRNA

ENST00000433433, ENST00000434764, ENST00000454183, ENST00000651283, ENST00000653517, ENST00000686170, ENST00000686982, ENST00000689274, ENST00000691292, ENST00000692191, ENST00000701008, ENST00000734122, ENST00000734123, ENST00000734124, ENST00000734125, ENST00000734126, ENST00000734127, ENST00000734128, ENST00000734129, ENST00000734130, ENST00000734131, ENST00000734132, ENST00000734133, ENST00000734134, ENST00000734135, ENST00000734136, ENST00000734137, ENST00000734138, ENST00000734139, ENST00000734140, ENST00000734141, ENST00000734142, ENST00000734143, ENST00000734144, ENST00000734145, ENST00000734146, ENST00000734147, ENST00000734148, ENST00000734149, ENST00000734150, ENST00000734151

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433433 — 2 exons

Exon	Start	End
ENSE00001650336	104865497	104868392
ENSE00001749732	104872246	104872452

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 92.01.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3299 / max 26.7918, expressed in 144 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
30015	0.1503	85
30014	0.0957	50
30013	0.0590	38
30012	0.0250	10

Top tissues by expression

212 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	92.01	gold quality
kidney epithelium	UBERON:0004819	89.86	gold quality
metanephros cortex	UBERON:0010533	88.07	gold quality
ganglionic eminence	UBERON:0004023	87.75	gold quality
renal medulla	UBERON:0000362	85.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.32	gold quality
adult mammalian kidney	UBERON:0000082	82.94	gold quality
metanephros	UBERON:0000081	82.01	gold quality
left ventricle myocardium	UBERON:0006566	81.43	gold quality
cardiac muscle of right atrium	UBERON:0003379	81.29	gold quality
kidney	UBERON:0002113	81.12	gold quality
cortex of kidney	UBERON:0001225	79.63	gold quality
upper arm skin	UBERON:0004263	76.99	gold quality
putamen	UBERON:0001874	72.89	gold quality
corpus epididymis	UBERON:0004359	72.75	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.46	gold quality
spinal cord	UBERON:0002240	71.54	gold quality
corpus callosum	UBERON:0002336	71.44	gold quality
nucleus accumbens	UBERON:0001882	71.24	gold quality
caudate nucleus	UBERON:0001873	71.19	gold quality
amygdala	UBERON:0001876	71.18	gold quality
anterior cingulate cortex	UBERON:0009835	70.96	gold quality
pancreatic ductal cell	CL:0002079	70.69	silver quality
substantia nigra	UBERON:0002038	70.36	gold quality
cortical plate	UBERON:0005343	69.98	gold quality
cerebellar vermis	UBERON:0004720	69.43	gold quality
midbrain	UBERON:0001891	69.40	gold quality
prefrontal cortex	UBERON:0000451	69.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.74	gold quality
right frontal lobe	UBERON:0002810	68.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.