LINC01170

Summary

LINC01170 (long intergenic non-protein coding RNA 1170, HGNC:49542) is a long non-coding RNA gene on chromosome 5q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49542
Approved symbol	LINC01170
Name	long intergenic non-protein coding RNA 1170
Location	5q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253807
Ensembl biotype	lncRNA
Entrez	103724389
RNAcentral	URS00007E50A4 — lncRNA, 737 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 29 lncRNA

ENST00000519703, ENST00000628324, ENST00000653233, ENST00000657766, ENST00000662643, ENST00000750061, ENST00000750062, ENST00000750063, ENST00000750064, ENST00000750065, ENST00000750066, ENST00000750067, ENST00000750068, ENST00000750069, ENST00000750070, ENST00000750071, ENST00000750072, ENST00000750073, ENST00000750074, ENST00000750075, ENST00000750076, ENST00000750077, ENST00000750078, ENST00000750079, ENST00000750080, ENST00000750081, ENST00000750082, ENST00000750083, ENST00000750084

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000519703 — 6 exons

Exon	Start	End
ENSE00002090056	124314317	124314378
ENSE00002106433	124306230	124306291
ENSE00002125216	124386229	124386273
ENSE00002133189	124313590	124313700
ENSE00004094172	124438389	124438589
ENSE00004094186	124404954	124405085

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 83.07.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3189 / max 57.3245, expressed in 73 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
63161	0.1750	62
63162	0.0829	51
63160	0.0609	29

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	83.07	gold quality
right atrium auricular region	UBERON:0006631	82.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	81.50	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.70	gold quality
apex of heart	UBERON:0002098	73.64	gold quality
heart	UBERON:0000948	73.17	gold quality
substantia nigra	UBERON:0002038	72.74	gold quality
heart left ventricle	UBERON:0002084	70.17	gold quality
Ammon’s horn	UBERON:0001954	69.52	gold quality
amygdala	UBERON:0001876	68.77	gold quality
temporal lobe	UBERON:0001871	68.62	gold quality
putamen	UBERON:0001874	67.99	gold quality
hypothalamus	UBERON:0001898	64.74	gold quality
caudate nucleus	UBERON:0001873	64.63	gold quality
primary visual cortex	UBERON:0002436	64.07	gold quality
prefrontal cortex	UBERON:0000451	63.93	gold quality
nucleus accumbens	UBERON:0001882	62.59	gold quality
brain	UBERON:0000955	61.49	gold quality
cerebral cortex	UBERON:0000956	61.44	gold quality
stromal cell of endometrium	CL:0002255	61.17	gold quality
frontal cortex	UBERON:0001870	61.02	gold quality
ganglionic eminence	UBERON:0004023	60.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.52	gold quality
cortical plate	UBERON:0005343	60.37	gold quality
skeletal muscle tissue	UBERON:0001134	60.13	gold quality
gall bladder	UBERON:0002110	60.13	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	59.17	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	59.04	gold quality
anterior cingulate cortex	UBERON:0009835	58.50	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• High LINC01170 promotes the progression of endometrial carcinoma through stimulating proliferation, cell cycle transition and inhibiting apoptosis of endometrial carcinoma cells via AKT pathway. (PMID:30610803)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.