LINC01186

Summary

LINC01186 (long intergenic non-protein coding RNA 1186, HGNC:49573) is a long non-coding RNA gene on chromosome Xp11.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49573
Approved symbol	LINC01186
Name	long intergenic non-protein coding RNA 1186
Location	Xp11.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ZNF674-1
Ensembl gene	ENSG00000236751
Ensembl biotype	lncRNA
Entrez	101927574
RNAcentral	URS0000759D9D — lncRNA, 655 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000446884, ENST00000658351, ENST00000660228, ENST00000668280, ENST00000670979, ENST00000686272, ENST00000702012, ENST00000816075, ENST00000816076, ENST00000816077, ENST00000816078, ENST00000816079, ENST00000816080, ENST00000816081, ENST00000816082

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000446884 — 2 exons

Exon	Start	End
ENSE00001797372	46325788	46326454
ENSE00003866740	46327304	46327633

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 86.57.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8021 / max 56.7863, expressed in 300 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199054	0.5830	238
199055	0.2191	119

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	86.57	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.58	silver quality
heart left ventricle	UBERON:0002084	81.12	gold quality
cardiac ventricle	UBERON:0002082	80.66	gold quality
heart right ventricle	UBERON:0002080	73.72	silver quality
heart	UBERON:0000948	73.46	gold quality
metanephros cortex	UBERON:0010533	72.55	gold quality
left adrenal gland cortex	UBERON:0035825	72.11	gold quality
left adrenal gland	UBERON:0001234	71.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.23	gold quality
right adrenal gland cortex	UBERON:0035827	71.06	gold quality
right adrenal gland	UBERON:0001233	71.00	gold quality
adrenal cortex	UBERON:0001235	69.69	gold quality
left lobe of thyroid gland	UBERON:0001120	68.83	gold quality
adrenal gland	UBERON:0002369	67.99	gold quality
right lung	UBERON:0002167	67.79	gold quality
right lobe of thyroid gland	UBERON:0001119	67.78	gold quality
thyroid gland	UBERON:0002046	67.19	gold quality
buccal mucosa cell	CL:0002336	66.62	gold quality
right uterine tube	UBERON:0001302	66.05	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.82	gold quality
right atrium auricular region	UBERON:0006631	65.08	gold quality
esophagus mucosa	UBERON:0002469	64.78	gold quality
cardiac atrium	UBERON:0002081	64.54	gold quality
gall bladder	UBERON:0002110	64.24	gold quality
cortex of kidney	UBERON:0001225	63.57	gold quality
body of pancreas	UBERON:0001150	63.49	gold quality
metanephros	UBERON:0000081	63.05	gold quality
minor salivary gland	UBERON:0001830	62.98	gold quality
pigmented layer of retina	UBERON:0001782	62.29	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01186, a mediator of TGF-beta signaling, can play a significant role in the regulation of epithelial-mesenchymal transition and lung cancer cell migration and invasion. (PMID:28119085)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.