LINC01189

Summary

LINC01189 (long intergenic non-protein coding RNA 1189, HGNC:49592) is a long non-coding RNA gene on chromosome 9q13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49592
Approved symbol	LINC01189
Name	long intergenic non-protein coding RNA 1189
Location	9q13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232827
Ensembl biotype	lncRNA
Entrez	643648
RNAcentral	URS000075B5AE — lncRNA, 1193 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 35 lncRNA

ENST00000377614, ENST00000428440, ENST00000452826, ENST00000654178, ENST00000717388, ENST00000717389, ENST00000717390, ENST00000717391, ENST00000717392, ENST00000717393, ENST00000717394, ENST00000717395, ENST00000717396, ENST00000717397, ENST00000717398, ENST00000717399, ENST00000717400, ENST00000717401, ENST00000717402, ENST00000717403, ENST00000717404, ENST00000717405, ENST00000717406, ENST00000754626, ENST00000754627, ENST00000754628, ENST00000754629, ENST00000754630, ENST00000754631, ENST00000754632, ENST00000754633, ENST00000754634, ENST00000754635, ENST00000754636, ENST00000754637

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000377614 — 3 exons

Exon	Start	End
ENSE00002272994	62376135	62376813
ENSE00004032425	62432876	62432979
ENSE00004102850	62434067	62435981

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 81.11.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.11	gold quality
bone marrow cell	CL:0002092	79.16	gold quality
skeletal muscle tissue	UBERON:0001134	61.14	silver quality
liver	UBERON:0002107	57.40	gold quality
cortical plate	UBERON:0005343	57.23	silver quality
calcaneal tendon	UBERON:0003701	56.12	silver quality
hindlimb stylopod muscle	UBERON:0004252	55.67	silver quality
fundus of stomach	UBERON:0001160	53.97	gold quality
blood	UBERON:0000178	51.17	gold quality
lymph node	UBERON:0000029	50.93	silver quality
prefrontal cortex	UBERON:0000451	50.36	silver quality
left adrenal gland cortex	UBERON:0035825	49.86	gold quality
muscle layer of sigmoid colon	UBERON:0035805	49.08	gold quality
islet of Langerhans	UBERON:0000006	48.55	silver quality
muscle of leg	UBERON:0001383	48.08	silver quality
primary visual cortex	UBERON:0002436	47.26	silver quality
small intestine	UBERON:0002108	47.16	gold quality
colon	UBERON:0001155	47.07	gold quality
intestine	UBERON:0000160	47.03	gold quality
duodenum	UBERON:0002114	46.95	silver quality
gastrocnemius	UBERON:0001388	46.82	silver quality
descending thoracic aorta	UBERON:0002345	46.69	gold quality
lower esophagus muscularis layer	UBERON:0035833	46.54	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	46.11	gold quality
corpus callosum	UBERON:0002336	46.10	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	45.80	gold quality
adrenal tissue	UBERON:0018303	45.77	silver quality
esophagus	UBERON:0001043	45.69	gold quality
kidney	UBERON:0002113	45.61	silver quality
monocyte	CL:0000576	45.40	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA LINC01189 is associated with HCV-hepatocellular carcinoma and regulates cancer cell proliferation and chemoresistance through hsa-miR-155-5p. (PMID:33059056)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.