LINC01198

Summary

LINC01198 (long intergenic non-protein coding RNA 1198, HGNC:49598) is a long non-coding RNA gene on chromosome 13q14.13.

Biomarker of malignant astrocytoma.

Source: NCBI Gene 101929344 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49598
Approved symbol	LINC01198
Name	long intergenic non-protein coding RNA 1198
Location	13q14.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231817
Ensembl biotype	lncRNA
Entrez	101929344
RNAcentral	URS000075CADA — lncRNA, 955 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 63 — 63 lncRNA

ENST00000416521, ENST00000458282, ENST00000593640, ENST00000594153, ENST00000594428, ENST00000598084, ENST00000599175, ENST00000647588, ENST00000647744, ENST00000647756, ENST00000647866, ENST00000647922, ENST00000648041, ENST00000648133, ENST00000648245, ENST00000648255, ENST00000648333, ENST00000648348, ENST00000648471, ENST00000648492, ENST00000648986, ENST00000649546, ENST00000649910, ENST00000650240, ENST00000650383, ENST00000650465, ENST00000653039, ENST00000653919, ENST00000655282, ENST00000655939, ENST00000656994, ENST00000657077, ENST00000658378, ENST00000658922, ENST00000659419, ENST00000659597, ENST00000660764, ENST00000661606, ENST00000661995, ENST00000663219, ENST00000663664, ENST00000663741, ENST00000664096, ENST00000664325, ENST00000665124, ENST00000666107, ENST00000667460, ENST00000667917, ENST00000668563, ENST00000669385, ENST00000670134, ENST00000670209, ENST00000671320, ENST00000671405, ENST00000781180, ENST00000781181, ENST00000781182, ENST00000781183, ENST00000781184, ENST00000781185, ENST00000781186, ENST00000781187, ENST00000781188

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416521 — 4 exons

Exon	Start	End
ENSE00001714099	46457840	46457913
ENSE00003098949	46464675	46464750
ENSE00003202706	46466609	46466783
ENSE00003841115	46455291	46455511

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 88.16.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3419 / max 39.0389, expressed in 106 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137216	0.2664	81
137215	0.0754	33

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.16	gold quality
left testis	UBERON:0004533	86.14	gold quality
right testis	UBERON:0004534	85.85	gold quality
testis	UBERON:0000473	85.70	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.82	gold quality
bone marrow cell	CL:0002092	70.68	gold quality
mucosa of stomach	UBERON:0001199	69.19	gold quality
tibial nerve	UBERON:0001323	65.82	gold quality
prostate gland	UBERON:0002367	65.64	gold quality
colonic epithelium	UBERON:0000397	65.35	silver quality
thoracic mammary gland	UBERON:0005200	64.36	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.23	gold quality
lower esophagus	UBERON:0013473	63.14	gold quality
tonsil	UBERON:0002372	63.13	gold quality
urinary bladder	UBERON:0001255	62.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.57	gold quality
stromal cell of endometrium	CL:0002255	62.50	gold quality
calcaneal tendon	UBERON:0003701	61.93	gold quality
ventricular zone	UBERON:0003053	61.85	gold quality
uterine cervix	UBERON:0000002	60.88	gold quality
ganglionic eminence	UBERON:0004023	60.78	gold quality
ectocervix	UBERON:0012249	60.53	gold quality
sural nerve	UBERON:0015488	60.45	silver quality
descending thoracic aorta	UBERON:0002345	60.38	gold quality
skin of leg	UBERON:0001511	60.32	gold quality
endocervix	UBERON:0000458	60.09	gold quality
thoracic aorta	UBERON:0001515	59.57	gold quality
ascending aorta	UBERON:0001496	59.51	gold quality
zone of skin	UBERON:0000014	59.31	gold quality
bone marrow	UBERON:0002371	58.50	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LINC01198 facilitates gliomagenesis through activating PI3K/AKT pathway. (PMID:32378450)
• LINC01198 promotes colorectal cancer cell proliferation and inhibits apoptosis via Notch signaling pathway. (PMID:32894550)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.