LINC01220

Summary

LINC01220 (long intergenic non-protein coding RNA 1220, HGNC:49664) is a long non-coding RNA gene on chromosome 14q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49664
Approved symbol	LINC01220
Name	long intergenic non-protein coding RNA 1220
Location	14q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259687
Ensembl biotype	lncRNA
Entrez	731223
RNAcentral	URS0000759963 — lncRNA, 501 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000558575, ENST00000561000, ENST00000665235, ENST00000669323, ENST00000701430, ENST00000776993, ENST00000776994, ENST00000776995, ENST00000776996, ENST00000776997, ENST00000776998, ENST00000776999, ENST00000777000, ENST00000790296

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558575 — 3 exons

Exon	Start	End
ENSE00002568814	75294677	75294737
ENSE00004145266	75294343	75294541
ENSE00004145270	75296120	75296863

Expression profiles

Bgee: expression breadth ubiquitous, 150 present calls, max score 84.66.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5605 / max 90.7645, expressed in 551 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140660	0.9374	333
140659	0.4207	191
140661	0.2024	84

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	84.66	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.74	gold quality
bone marrow cell	CL:0002092	76.88	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.61	silver quality
colonic epithelium	UBERON:0000397	70.49	silver quality
leukocyte	CL:0000738	70.47	gold quality
monocyte	CL:0000576	70.40	gold quality
apex of heart	UBERON:0002098	65.03	gold quality
right atrium auricular region	UBERON:0006631	64.48	gold quality
cardiac atrium	UBERON:0002081	63.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	61.72	gold quality
stromal cell of endometrium	CL:0002255	61.10	gold quality
anterior cingulate cortex	UBERON:0009835	60.11	gold quality
blood	UBERON:0000178	59.97	gold quality
cortical plate	UBERON:0005343	59.64	silver quality
heart left ventricle	UBERON:0002084	59.63	gold quality
right adrenal gland cortex	UBERON:0035827	59.35	gold quality
heart	UBERON:0000948	58.96	gold quality
cardiac ventricle	UBERON:0002082	58.95	gold quality
ganglionic eminence	UBERON:0004023	58.75	gold quality
smooth muscle tissue	UBERON:0001135	58.63	gold quality
prefrontal cortex	UBERON:0000451	58.52	gold quality
right adrenal gland	UBERON:0001233	58.30	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.37	gold quality
adrenal tissue	UBERON:0018303	57.33	gold quality
adult mammalian kidney	UBERON:0000082	57.25	gold quality
omental fat pad	UBERON:0010414	56.80	gold quality
peritoneum	UBERON:0002358	56.75	gold quality
metanephros cortex	UBERON:0010533	56.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Knocking down of LINC01220 inhibits proliferation and induces apoptosis of endometrial carcinoma through silencing MAPK11. (PMID:31123170)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.