LINC01221

Summary

LINC01221 (long intergenic non-protein coding RNA 1221, HGNC:49671) is a long non-coding RNA gene on chromosome 1q32.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49671
Approved symbol	LINC01221
Name	long intergenic non-protein coding RNA 1221
Location	1q32.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00000366
Ensembl gene	ENSG00000235492
Ensembl biotype	lncRNA
Entrez	104266961
RNAcentral	URS00001DBFD9 — lncRNA, 662 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000432488, ENST00000782914

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432488 — 3 exons

Exon	Start	End
ENSE00001658590	199016133	199016465
ENSE00001702638	199076524	199076735
ENSE00001723310	199041556	199041672

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 63.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0346 / max 40.8318, expressed in 6 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
7625	0.0188	4
7624	0.0126	3
7626	0.0033	1

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tonsil	UBERON:0002372	63.80	gold quality
ganglionic eminence	UBERON:0004023	62.05	gold quality
amygdala	UBERON:0001876	59.47	gold quality
corpus callosum	UBERON:0002336	57.03	gold quality
prefrontal cortex	UBERON:0000451	52.30	silver quality
stomach	UBERON:0000945	51.80	silver quality
monocyte	CL:0000576	48.84	silver quality
Ammon’s horn	UBERON:0001954	47.60	gold quality
brain	UBERON:0000955	46.77	gold quality
multicellular organism	UBERON:0000468	44.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	42.37	gold quality
substantia nigra	UBERON:0002038	42.27	silver quality
caudate nucleus	UBERON:0001873	41.12	silver quality
putamen	UBERON:0001874	41.10	silver quality
apex of heart	UBERON:0002098	39.96	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	39.43	silver quality
subcutaneous adipose tissue	UBERON:0002190	38.06	silver quality
lower esophagus muscularis layer	UBERON:0035833	37.48	silver quality
esophagus mucosa	UBERON:0002469	37.40	silver quality
small intestine Peyer’s patch	UBERON:0003454	36.52	silver quality
right frontal lobe	UBERON:0002810	36.36	silver quality
hypothalamus	UBERON:0001898	34.01	silver quality
testis	UBERON:0000473	32.39	silver quality
left testis	UBERON:0004533	28.21	silver quality
right testis	UBERON:0004534	26.38	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.95

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.