LINC01224

Summary

LINC01224 (long intergenic non-protein coding RNA 1224, HGNC:49676) is a long non-coding RNA gene on chromosome 19p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49676
Approved symbol	LINC01224
Name	long intergenic non-protein coding RNA 1224
Location	19p12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000269416
Ensembl biotype	lncRNA
Entrez	104472717
RNAcentral	URS00007E4CDE — lncRNA, 2564 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 48 — 48 lncRNA

ENST00000593573, ENST00000594576, ENST00000596283, ENST00000596763, ENST00000598922, ENST00000600643, ENST00000601293, ENST00000601338, ENST00000602077, ENST00000654756, ENST00000684878, ENST00000688559, ENST00000817170, ENST00000817171, ENST00000817172, ENST00000817173, ENST00000817174, ENST00000817175, ENST00000817176, ENST00000817177, ENST00000817178, ENST00000817179, ENST00000817180, ENST00000817181, ENST00000817182, ENST00000817183, ENST00000817184, ENST00000817185, ENST00000817186, ENST00000817187, ENST00000817188, ENST00000817189, ENST00000817190, ENST00000817191, ENST00000817192, ENST00000817193, ENST00000817194, ENST00000817195, ENST00000817196, ENST00000817197, ENST00000817198, ENST00000817199, ENST00000817200, ENST00000817201, ENST00000817202, ENST00000817203, ENST00000817204, ENST00000817205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000593573 — 6 exons

Exon	Start	End
ENSE00002983524	23400984	23401047
ENSE00003001737	23403720	23403747
ENSE00003099412	23404951	23405108
ENSE00003144777	23405258	23405335
ENSE00004220685	23415894	23416186
ENSE00004220710	23403206	23403509

Expression profiles

Bgee: expression breadth ubiquitous, 148 present calls, max score 84.73.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7536 / max 66.7570, expressed in 278 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180274	1.1365	265
180273	0.6170	176

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	84.73	gold quality
ventricular zone	UBERON:0003053	84.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.34	gold quality
sperm	CL:0000019	83.64	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.53	gold quality
rectum	UBERON:0001052	78.69	gold quality
mucosa of transverse colon	UBERON:0004991	77.26	gold quality
cortical plate	UBERON:0005343	76.16	gold quality
ileal mucosa	UBERON:0000331	74.95	gold quality
right testis	UBERON:0004534	73.60	gold quality
colonic epithelium	UBERON:0000397	73.07	gold quality
left testis	UBERON:0004533	72.67	gold quality
buccal mucosa cell	CL:0002336	70.79	gold quality
testis	UBERON:0000473	70.79	gold quality
transverse colon	UBERON:0001157	70.60	gold quality
tibialis anterior	UBERON:0001385	70.20	silver quality
pancreatic ductal cell	CL:0002079	68.51	silver quality
sural nerve	UBERON:0015488	66.13	gold quality
small intestine	UBERON:0002108	64.60	gold quality
duodenum	UBERON:0002114	64.47	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.27	gold quality
intestine	UBERON:0000160	61.95	gold quality
colon	UBERON:0001155	61.14	gold quality
large intestine	UBERON:0000059	60.62	gold quality
jejunal mucosa	UBERON:0000399	59.81	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.51	silver quality
adrenal tissue	UBERON:0018303	59.08	gold quality
deltoid	UBERON:0001476	57.64	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.75	gold quality
lower esophagus mucosa	UBERON:0035834	55.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.36

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467. (PMID:34403779)
• LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis. (PMID:34535152)
• Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis. (PMID:36127622)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.