LINC01226

Summary

LINC01226 (long intergenic non-protein coding RNA 1226, HGNC:49678) is a long non-coding RNA gene on chromosome 1p35.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49678
Approved symbol	LINC01226
Name	long intergenic non-protein coding RNA 1226
Location	1p35.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	SEELA2
Ensembl gene	ENSG00000284543
Ensembl biotype	lncRNA
Entrez	284551
RNAcentral	URS000056F2F3 — lncRNA, 2741 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000638644, ENST00000639047, ENST00000639741, ENST00000639839, ENST00000639946, ENST00000640157, ENST00000640226, ENST00000640623, ENST00000640630, ENST00000763158, ENST00000836672, ENST00000836673

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638644 — 5 exons

Exon	Start	End
ENSE00003804302	31568166	31568280
ENSE00003805528	31522206	31522236
ENSE00003808085	31536272	31536409
ENSE00003808131	31551535	31551657
ENSE00003810900	31552430	31552563

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 94.81.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8857 / max 407.5137, expressed in 48 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
1915	0.8354	47
1914	0.0503	16

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	94.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.95	silver quality
mucosa of transverse colon	UBERON:0004991	79.37	gold quality
metanephros cortex	UBERON:0010533	75.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.97	gold quality
bone marrow cell	CL:0002092	70.72	silver quality
endocervix	UBERON:0000458	69.62	gold quality
metanephros	UBERON:0000081	68.65	gold quality
cortex of kidney	UBERON:0001225	68.57	gold quality
rectum	UBERON:0001052	68.12	gold quality
transverse colon	UBERON:0001157	66.69	gold quality
colonic epithelium	UBERON:0000397	65.10	silver quality
spleen	UBERON:0002106	64.77	gold quality
vena cava	UBERON:0004087	63.77	gold quality
sural nerve	UBERON:0015488	63.57	silver quality
lymph node	UBERON:0000029	63.34	gold quality
monocyte	CL:0000576	63.28	gold quality
lateral globus pallidus	UBERON:0002476	63.09	gold quality
oocyte	CL:0000023	62.97	gold quality
leukocyte	CL:0000738	62.89	gold quality
adult mammalian kidney	UBERON:0000082	62.71	gold quality
cortical plate	UBERON:0005343	62.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	62.56	gold quality
subthalamic nucleus	UBERON:0001906	62.24	gold quality
substantia nigra pars compacta	UBERON:0001965	62.18	gold quality
sperm	CL:0000019	62.08	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.02	gold quality
inferior vagus X ganglion	UBERON:0005363	62.01	gold quality
ascending aorta	UBERON:0001496	61.69	gold quality
ventral tegmental area	UBERON:0002691	61.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LINC01226 promotes gastric cancer progression through enhancing cytoplasm-to-nucleus translocation of STIP1 and stabilizing beta-catenin protein. (PMID:37806517)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.